THYROID Flashcards
how does the negative feedback loop work?
hypothalamus releases TRH > pituitary releases TSH > thyroid releases TH
once hypothalamus senses enough TH, will stop releasing TRH
graves disease labs
TRAb
in which group of patients is routine screening required
pediatrics and pregnant women
how do nsaids affect t4 level
NSAIDs can increase free T4 level
which drug has a boxed risk of hepatotoxicity
ptu
when to recheck t4 levels upon therapy initiation or modification
4-8 weeks
how does amiodarone affect thyroid function
contains iodide, `can cause rise or fall in t3 and t4 levels directly
3 potential adverse effects of excessive thyroid replacement
atrial fibrillation, osteoporosis,
sx of hyperthyroidism
which drug is teratogenic
carbimazole, but only avoid in 1st stage of preg.
what is the dose conversion of methimazole to ptu, and when should you recheck thyroid levels when changing drug
1:10
2 weeks later, then at 2 to 4 weeks interval
subclinical hypothyroidism (TSH, T4) / how to know when a pt is non adherent to levothy
elevated TSH, normal T4
subclinical hyperthyroidism (TSH, T4)
low TSH, normal T4
how to dose levothyroxine in young healthy adults
1.6mcg/kg/d
how to dose levothy in adults 50-60yrs of age without cvd
50 mcg per day
hypothyroidism (tsh, t4) and what antibodies
high tsh, low t4
TPO, ATgA
