MSK Flashcards
gout
1
Q
how do xanthine oxidase inhibitors work
A
impair conversion of hypoxanthine to xanthine to uric acid
2
Q
side effects of allopurinol
A
skin rash, leukopenia, GI problems, headache, urticaria
3
Q
febuxostat side effects
A
nausea, arthralgias, hepatic transaminase elevationb
4
Q
benefit of febuxostat vs allo
A
allo need dose adjustment
5
Q
how do uricosurics work
A
inhibit renal proximal tubular reabsorption of uric acid
6
Q
creatinine clearance for probenecid
A
crcl must be more than 30
7
Q
side effects of probenecid
A
GI irrritation, rash, hypersensitivity, precipitation of acute gouty arthritis, urolithiasis
8
Q
max dose of probenecid
A
3g
9
Q
other drugs with uricosuric effect
A
losartan, fenofibrate
10
Q
gout non-pharm
A
- low purine diet
- limit alcohol intake
- exercise/weight loss
- avoid fructose
11
Q
minimal anti-inflammatory prophylaxis
A
6m
12
Q
A
