DM Flashcards
which 2 classes of DM meds increase insulin sensitivity
metformin (biguanide)
TZD
which class (1) of DM meds increase insulin secretion
SU, bind to sulfonylurea receptor on pancreatic b cells
which class (1) of DM meds delay glucose absorption
alpha glucosidase inhibitors
which class (1) of DM meds increase glucose excretion
sglt2i
pt has UC/CD, what DM meds to avoid
alpha glucosidase
pt has heart failure, what DM meds to avoid
tzd
pt has hx of pancreatitis, what dm meds to avoid
glp1 / gliptins
cut off egfr for empa and dapa
empa 20
dapa 25
why impaired insulin secretion in t2dm
beta cell mass and function reduced
why does reduced incretin effect occur
decreased concentrations of / resistance to effects of incretin hormones
why increased insulin resistance
excessive hepatic glucose production
why excess glucagon secretion
glp1 and insulin resistance / deficiency, suppressing glucagon
toujeo can keep in room temperature for
6 weeks
lantus can keep in room temperature for
4 weeks
actrapid flexpen can keep in room temperature for
6 weeks
do longer acting products have a higher or lower risk of nocturnal hypoglycemia
lower risk
during acute ilness or ketosis, do you need higher or lower insulin doses
higher
what does metformin do to the liver
decrease hepatic glucose production
why does metformin have low hypoglycemic risk
does not directly increase pancreatic insulin secretion
does metformin affect cholesterol
decreases tg levels and ldlc
increases hdl
metformin can cause deficiency of
vb12 cyanocobalamin
which grp of pts are more susceptible to lactic acidosis when it comes to metformin
renal insufficiency, heart failure, hepatic impairment, alcoholism
alpha glucosidase cut off in renal pts
crcl <25
how does pioglitazone (tzd) affect tg
decrease tg
