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Question 1

which pde5i can treat BPH, and how

Answer 1

tadalafil. increases cyclic gmp, relaxing smooth muscles

Question 2

amongst silodosin, tamsulosin and alfuzosin, which one does not need renal adjustment

Answer 2

tamsulosin

Question 3

why cannot donate blood when using 5ARI eg finasteride

Answer 3

teratogenic

Question 4

floppy iris syndrome avoid which alpha blocker

Answer 4

tamsulosin

Question 5

scoring system for bph

Answer 5

1-7: mild
8-19: moderate
20-35: severe

Question 6

which alpha blockers are selective (TAS)

Answer 6

tamsulosin
alfuzosin
silodosin

Question 7

which alpha blockers are not selective (PTD)

Answer 7

prazosin
terazosin
doxazosin

Question 8

which type of alpha blockers give rise to high tendency of ED

Answer 8

uroselective TAS

Question 9

difference between dutasteride and finasteride

Answer 9

dutasteride inhibits type 1 and 2 5ARI, finasteride only inhibits type 2

Question 10

what is mirabegron

Answer 10

beta 3 adrenergic agonist, relaxes bladder muscle

Question 11

why is mirabegron preferred over solifenacin / oxybutynin / tolteroldine

Answer 11

does not display antichol side effects eg dry mouth

the rest are anticholinergics

Question 12

what causes the enlargement of the prostate

Answer 12

conversion from testosterone to dihydrotestosterone

Question 13

what causes the narrowing of the urethra outlet

Answer 13

increased agonism of alpha 1 receptors of smooth muscle tissue

Question 14

side effects of Ed meds

Answer 14

headache, flushing, dyspepsia, nasal congestion, dizziness

Question 15

list 2 mechanisms of erection (smooth muscle relaxation and increased blood flow)

Answer 15

1. nitric oxide -> cGMP
2. prostaglandins -> cAMP

Question 16

what is an adverse visual effect of ED meds

Answer 16

retinitis pigmentosa (issue with blue and green lights) or visual disturbances

Question 17

side effect of tadalafil due to type 2 phosphodiesterase

Answer 17

back and muscle pain