TB

Question 1

dosing for RIPE drugs in tb

Answer 1

isoniazid: 5 mg/kg (300 mg)
rifampin: 10 mg/kg (600 mg)
pyrazinamide: 1g (<55kg), 1.5g (55-75kg), 2g (>75kg)
ethambutol: 800mg, 1200mg, 1600mg (same as pyr)

Question 2

what to measure for tb treatment before initiation

Answer 2

lft

Question 3

which of the ripe drugs are nephrotoxic vs hepatotoxic

Answer 3

hep: RIP
neph: PE

Question 4

DDI of rifampicin

Answer 4

induction of cyp450 enzymes

Question 5

which of the ripe need to take before food

Answer 5

ri

Question 6

what is the test for tb

Answer 6

Tested positive for Ziehl-Neelsen stain for acid fast bacilli

Question 7

which of the ripe gives rise to Orange discoloration of bodily fluids

Answer 7

r

Question 8

which of the ripe is given in given in combi with VitK (to avoid thrombocytopenia)

Answer 8

r

Question 9

when to give pyridoxine in ripe, which drug causes the need. and why need

Answer 9

Pregnancy / B6 deficiency / Breastfeeding

isoniazid

Peripheral neuropathy (inhibits formation of active VitB6 aka pyridoxine needed for CNS)

Question 10

isoniazid need to avoid what food

Answer 10

Avoid concomitant intake of tyramine, histamine

Question 11

which of the ripe are prodrugs

Answer 11

IP

Question 12

which of the ripe penetrates cns

Answer 12

ip

Question 13

which of the drugs need renal adjustment below crcl 30

Answer 13

pyrazinamide

Question 14

which of the ripe can cause gout

Answer 14

pe

Question 15

which ripe can cause visual toxicity

Answer 15

e

Question 16

first line for idsa

Answer 16

rie

pyrazinamide for resistant tb

Question 17

safest drug for pregnancy in ripe

Answer 17

e