Thrombolytic (Fibrinolytic) Agents

Question 1

The central process of _____ is the conversion of inactive plasminogen to the active proteolytic enzyme plasmin.

Answer 1

fibrinolysis

Question 2

The central process of fibrinolysis is the conversion of inactive ______ to the active proteolytic enzyme _____.

Answer 2

plasminogen; plasmin

Question 3

All fibrinolytic drugs produce rapid lysis of thrombi by increasing formation of ______ from ______.

Answer 3

plasmin; plasminogen

Question 4

How does Streptokinase (Streptase) work?

Answer 4

converts uncomplexed plasminogen to active plasmin- Generally results in systemic activation of plasmin

Question 5

This drug converts uncomplexed plasminogen to active plasmin- Generally results in systemic activation of plasmin.

Answer 5

Streptokinase (Streptase)

Question 6

How does Tissue Plasminogen Activator (tPA): Alteplase (Activase) work?

Answer 6

binds to fibrin and selectively activates bound plasminogen

Question 7

This drug binds to fibrin and selectively activates bound plasminogen.

Answer 7

Tissue Plasminogen Activator (tPA): Alteplase (Activase)

Question 8

What are Reteplase (Retevase) and Tenecteplase (TNKase)?

Answer 8

fibrinolytics that convert plasminogen into plasmin- they have a prolonged duration of action

Question 9

Which fibrinolytics have a prolonged duration of action?

Answer 9

Reteplase (Retevase) and Tenecteplase (TNKase)

Question 10

When are fibrinolytic agents used?

Answer 10

1. acute MI
2. DVT
3. multiple PE