Cardiovascular Disease and Depression

Question 1

_____ increases the risk of coronary artery disease

by 1.5-2.0 times in otherwise physically healthy individuals.

Answer 1

Depression

Question 2

Depression increases the risk of coronary artery disease

by _____ times in otherwise physically healthy individuals.

Answer 2

1.5-2.0

Question 3

What physiologic derangements are assoc with depression?

Answer 3

Autonomic dysfunction

Elevated cortisol

Platelet activation

Endothelial dysfunction

Inflammation

Question 4

_____ accounted for a significant portion of the risk of cardiovascular mortality due to depressive symptoms in older adults.

Answer 4

Physical inactivity

Question 5

Depressed pts are 2-4x less likely to?

Answer 5

1. adhere to meds
2. follow lifestyle recommendations
3. practice self-mgmt.
4. receive recommended testing
5. FU

Question 6

Depression tx improves which physiologic markers?

Answer 6

1. Significant decreases in platelet activation markers
2. Improved heart rate variability
3. Reduced inflammatory markers
4. Normalized brain serotonin turnover

Question 7

What are the first line depression txs?

Answer 7

1. SSRIs

2. Bupropion (Wellbutrin)