Antiplatelet Agents Flashcards

1
Q

How does aspirin work?

A

it inhibits COX-1 synthesis of thromboxane in platelets

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2
Q

What drug inhibits COX-1 synthesis of thromboxane in platelets?

A

aspirin

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3
Q

How do Clopidogrel (Plavix), Prasugrel (Effient), and Ticagrelor (Brilinta) work?

A

they’re ADP (purinergic-P2Y12) receptor antagonists that interfere with ADP-induced platelet aggregation.

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4
Q

These drugs are ADP (purinergic-P2Y12) receptor antagonists that interfere with ADP-induced platelet aggregation.

A

Clopidogrel (Plavix), Prasugrel (Effient), and Ticagrelor (Brilinta)

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5
Q

How does Dipyridamole (Persantine) work?

A

Blocks phosphodiesterase breakdown of cAMP, elevating cAMP levels and potentiating prostacyclin’s anti-aggregatory action

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6
Q

This drug blocks phosphodiesterase breakdown of cAMP, elevating cAMP levels and potentiating prostacyclin’s anti-aggregatory action.

A

Dipyridamole (Persantine)

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7
Q

How do Abciximab (Reopro), Eptifibatide (Integrelin), and Tirofiban (Aggrastat) work?

A

Blocks IIb/IIIa receptors on platelet thus preventing integrin and fibrinogen binding that facilitates aggregation (platelet-platelet binding).

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8
Q

These drugs block IIb/IIIa receptors on platelet, thus preventing integrin and fibrinogen binding that facilitates aggregation (platelet-platelet binding).

A

Abciximab (Reopro), Eptifibatide (Integrelin), and Tirofiban (Aggrastat)

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