Acute Coronary Syndrome Flashcards

1
Q

What is the persistence of cTnI?

A

3-10 days

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2
Q

What is the persistence of myoglobin?

A

24 hours

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3
Q

What is the persistence of cTnT?

A

7-10 days

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4
Q

What does ACS stand for?

A

acute coronary syndrome

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5
Q

What is the time to peak elevation of cTnT?

A

12-48 hours

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5
Q

What is the onset of detection of LD-I?

A

10-12 hours

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6
Q

Unstable angina?

A

discomfort which is new in onset or is increased in duration, frequency or intensity with less exertion or at rest compared to previous episodes of discomfort

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7
Q

How is STEMI treated?

A
  1. open the artery- give fibrinolytic if cath lab is >90 min away 2. reduce myocardial O2 demand w/ beta-blockers and nitrates (if stable)
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8
Q

What is STEMI?

A

Complete coronary vessel occlusion: ST elevation myocardial infarction (STEMI)

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9
Q

_____ is very sensitive and specific for myocardium.

A

Cardiac troponin

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10
Q

What is acute coronary syndrome (ACS)?

A

any array of clinical symptoms resulting from underlying acute myocardial ischemia

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11
Q

What is the persistence of LD-I?

A

7-10 days

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11
Q

How are NSTEMI or unstable angina treated?

A

halt the coagulation cascade (enoxaparin, heparins OR bival/thrombolytics) AND the platelet cascade (aspirin + P2Y12 inhibitor OR -ogrels OR GPIIb/IIIa inhibitor)

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13
Q

What is the onset of detection of cTnT?

A

4-6 hours

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13
Q

Partial coronary vessel occlusion, escalating symptoms without myocardial necrosis?

A

unstable angina

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14
Q

Stable angina?

A

present when there is increased demand for myocardial oxygen in a reproducible fashion

15
Q

present when there is increased demand for myocardial oxygen in a reproducible fashion

A

stable angina

16
Q

What is the onset of detection of myoglobin?

A

1-2 hours

18
Q

What is the time to peak elevation of cTnI?

A

12 hours

19
Q

What is the onset of detection of cTnI?

A

4-6 hours

20
Q

What is the onset of detection of CK-MB isoforms?

A

4-6 hours

21
Q

Dysfunctional endothelium + coagulation + platelet aggregation =

A

Coronary thrombosis

23
Q

What is the persistence of CK-MB isoforms?

A

2-4 days

24
Q

What is the time to peak elevation of LD-I?

A

48-72 hours

25
Q

Causes of ACS?

A

Atherosclerotic plaque rupture with thrombus Coronary embolism Congenital anomalies Coronary trauma or aneurysm Severe coronary artery spasm (e.g. cocaine) Increased blood viscosity Spontaneous coronary dissection Markedly increased myocardial O2 demand

26
Q

discomfort which is new in onset or is increased in duration, frequency or intensity with less exertion or at rest compared to previous episodes of discomfort

A

unstable angina

27
Q

What is the time to peak elevation of CK-MB isoforms?

A

18 hours

28
Q

What is NSTEMI?

A

Partial coronary vessel occlusion with myocardial necrosis: non ST elevation MI (NSTEMI)

29
Q

any array of clinical symptoms resulting from underlying acute myocardial ischemia

A

acute coronary syndrome (ACS)

30
Q

What is the time to peak elevation of myoglobin?

A

8-10 hours