Thrombocyte Abnormalities

Question 1

Virchow’s Triad - lists the factors that cause thrombosis.

Enumerate

Answer 1

Decreased blood flow (venous stasis) Inflammation of or near the blood vessels (vascular endothelial injury)
Activation of blood coagulation (hypercoagulable states)

Question 2

Identify

refers to the formation of an abnormal mass within the vascular system, arterial or venous, which comes from the constituents of blood

Answer 2

Thrombosis

Question 3

False about arterial thrombi
A. Red thrombus
B. Abnormal underlying vasculature
C. Composed of many platelets
D. Pathophysio is Local shear stress and thrombogenic vascular surface

Answer 3

A

White thrombus dapat

Question 4

False about venous thrombi
A. Red thrombus
B. Abnormal underlying vasculature
C. Composed of fibrin
D. Pathophysio is stasis and hypercoagulability

Answer 4

B

Normal dapat

Question 5

Which is not a predisposing factor for acquired thrombophilia?
A. Pregnancy
B. Disseminated intravascular coagulation
C. Decreasing age
D. Tissue Factor can be associated with microparticles

Answer 5

C

Increasing dapat

Question 6

Which is false?
A.all hormones produced in pregnancy are thrombogenic
B.increasing age is associated with increase in pro-coagulant markers
C.in DIC, endothelial cells can inhibit fibrinolysis

Answer 6

A

Some lang

Question 7

Enumerate two common causes of hereditary thrombophilia

Answer 7

Factor V Leiden deficiency Prothrombin G20210A

Question 8

Enumerate two rare causes of hereditary thrombophilia

Answer 8

Dysfibrinogenimia

Homozygous homocystinuria

Question 9

Screening tests for thrombophilias are not available except for ___ where can be used

Answer 9

APC resistance where PTT (Partial Thromboplastin Time) can be used

Question 10

False about pseudothrombocytopenia
A.Artificially low platelet count due to in vivo clumping of platelets
B.Usually caused by antibodies that bind platelets only in presence of chelating agent (EDTA)
C.also seen in healthy individuals

Answer 10

A

In vitro dapat

Question 11

Which is not a sign of pseudothrombocytopenia?
A.Marked fluctuations in platelet count without apparent cause B.Thrombocytopenia disproportionate
to symptoms
C.Clumped platelets on blood smear D.Platelets are stuck to RBCs

Answer 11

D

WBC dapat

Question 12

Amegakaryocytic thrombocytopenia that occurs in (pre-leukemia)

Identify

Answer 12

myelodysplasia

Question 13

o alcohol
o estrogens
 o thiazides  
o chlorpropamide
 o interferon 

They __ (inc, dec) platelet prof

Answer 13

Decrease

Question 14

Congenital aplastic anemia is also called __

Answer 14

Fanconi’s anemia

Question 15

Fill in the blanks

___ – May-Hegglin Anomaly and Bernard-Soulier’s Syndrome

___ – Wiskott-Aldrich Syndrome

Answer 15

Macrothrombocytopenia

Microthrombocytopenia

Question 16

What does hypercoagulable state mean?

Answer 16

group of inherited or acquired conditions associated with a predisposition to venous thrombosis, arterial thrombosis, or both