RBC Abnormalities Flashcards
Rouleaux Formation:short/long stacks of RBC. Seen in all except: A.Hyperproteinemia B.Atypical pneumonia C.Multiple Myeloma (MM) D.Pregnancy
B
autoagglutination is commonly seen in the ff except \_\_? A.hemolytic anemia B.Mycoplasma pneumonia C.staphylococcal infections D.schistosomiasis
D
Trypanosomiasis dapat
variation in Hb content is also called as __
Anisochromia
Hypochromia is commonly seen in all except A.iron deficiency anemia B.rheumatoid arthritis C.acute infections D.inflammation
C
False about hyperchromic blood A. Lacks central pallor, blood is too bright red B. Seen in sickle cell anemia C. Spherocytes may be detected D. true state if MCV is elevated
D
MCHC dapat
Macrocytic RBC is not seen in
A.B1 deficiency
B.Alcoholism, without liver disease C.Cancer chemotherapy
D.Chronic hemolytic anemia
A
B12 dapat
Megaloblastic anemia associated with achlorydia and lack of intrinsic factor necessary for the binding and absorption of vitamin B12.
Identify!
Pernicious anemia
RBC is thinner than normal and have colorless center (increased surface area, not proportional to the volume)
Identify
Leptocytes
Where are leptocytes not seen? A.thalassemia B.obstruction of pancreatic ducts C.cirrhosis D.steatorrhea
B
Bile dapat
Variation in shape, abnormal shape of cells
Identify
Poikilocytosis
Not a direct cause of poikilocytosis
A.structural changes in the cell membrane
B.A metabolic state in the cell C.Hemoglobin molecule abnormality
D.Person’s age
D
Red cell age dapat
Identify
Cell with irregular, long, assymettrical projections; specially seen with severe liver disease or post-splenoctomy; seen with rare disorder of abetalipoprteinemia
Acanthocyte
Identify
Similar to ring forms of malaria
Babesiosis
Identify
Small aggregates of RNAs are seen as small blue dots in the RBC;
Basophilic stippling
Elongated, elliptical cell; non-specific when occasionally seen; rare hereditary disorder
Identify
Elliptocyte
Identify
Precipitated Hgb seen as a perimembranous blue dot only after supravital staining, seen with some hemoglobinopathies
Heinz body
Identify
Small, round deeply basophilic nuclear remnant; seen when spleen is absent
Howell-Jolly body
Cells with decreased MCH, typical of iron deficiency
Identify
Hypochromia
Cells with increased MCH, typical of megaloblastic anemia
Macrocytic
Plasmodium infection seen as ‘ring forms’, stippling and gametocytes, depending upon the species
Identify
Malaria
Cells with decreased MCV, typical of iron deficiency anemia and thalassemia
Microcytosis
Multiple, tiny iron-containing granular blue dots; seen when spleen is absent and with iron overload
Identify
Pappenheimer body
Variation in shape of RBCs
Poikolicytosis
The bluish tint to young RBCs with high RNA content
Polychromatophilia
Identify
Young RBCs with increased RNA content that can be precipitated by supravital staining for identification and enumeration
Reticulocyte
Identify
Linear aggregation of RBCs that resembles stack of coins; when surface charge is reduced with increased serum protein, particularly increased fibrinogen or globulin
Rouleaux
Identify
Non-nucleated RBC with stainable iron
Sideroblast
Identify
Small, round dense cell without central pallor; suggests extravascular (splenic) hemolysis in previously normal persons;
Spherocytes
with hereditary spherocytosis there is increased osmotic fragility
T or F
T
Fragmented, irregularly shaped seen with intravascular hemolysis such as microangiopathic hemolytic anemias (DIC, TTP);
Identify
Schistocyte
Identify
Curved, banana-shaped cell with pointed ends found in sickle cell disease from aggregation of Hgb S
Sickle cell
Cell with slit-like central pallor;
Identify
Stomatocyte
Cell with central and peripheral staining with intervening pallor due to increased redundancy of RBC membrane; seen with liver disease, in some thalassemias and with high Hgb C
Identify
Target cell
Cell pinched at one end, prominent in myelofibrosis and myelophthisic conditions
Identify
Teardrop cell
Ovalocytes may be seen in: A. Sickle cell anemia B. Thalassemia C. autoimmune hemolytic anemia D. microangiopathic hemolytic anemia
A and B
Spherocytes may be seen in: A. Sickle cell anemia B. Thalassemia C. autoimmune hemolytic anemia D. microangiopathic hemolytic anemia
C and D
False about echinocytes
A. caused by release of substances from glass that changes pH and transform cells into echinocytes
B. In stored blood - increase of ATP and biochemical abnormalities in plasma
C. Not normally seen in vivo
D. Regarded as an artifact
B
Decrease dapat
Identify:
• spicules may be irregularly shaped, unevenly spaced
• Seen in renal insufficiency
• If seen in PBS should be reported
Burr cell
A.Caused by changes in the ratio of plasma lipids (lecithins and sphingomyelins)
B. Have irregularly spaced, few pointed spicules or thornlike projections of various lengths and widths to club shaped
C. Hereditary and acquired
Identify the abnormal RBC
acanthocyte
Identify RBC abnormal cell
- Elongated, with slit like area of pallor • Hereditary or acquired
- May be a result of high cellular sodium and low potassium content
- May be retained in the spleen because of abnormality
Stomatocyte
Identify RBC abnormal cell
- Central area of Hb surrounded by colorless ring and a peripheral ring of Hb
- Always acquired (No hereditary)
- Membrane surface is increased because of cholesterol and phospholipid loading
- Seen in THALASSEMIA
Codocyte
Serum - Plasma minus \_\_\_\_ A. Fibrinogen B. Thrombin C. WBC D. RBC
A
