Thiazolodinediones

Question 1

Is the medication T z d a hypoglycemic agent

Answer 1

Now, it does not increase insulin secretion

Question 2

What are T z d

Answer 2

Insulin sensitizers.

Improves sensitivity of muscle cells through activation of PPAR-g

Question 3

What are the two types of drugs in the T z d family

Answer 3

Pioglotazone (actos)

Rosiglitazone (avandia)

Question 4

What is the dose for actos

Answer 4

15-45 mg daily

Once daily, take with main meal, do not increase dose more than 4 weeks apart

Question 5

What is the dose for avandia

Answer 5

2-8mg daily. Do not increase dose is less than 4 weeks apart.
Can be daily or BID
take with main meal of the day, war with the two primary means of two daily doses are needed

Question 6

There is an increased risk of ________ when taking avandia

Answer 6

Cardiovascular disease, can increase risk of myocardial infarction by 30 to 40%.
This is different from Actos which suggests a beneficial effect on cardiovascular disease

Question 7

How long does it take to access full benefit of T z d

Answer 7

8 - 12 weeks

Question 8

Where are tzd metabolized

Answer 8

Liver

Question 9

How are tzd classified and pregnancy

Answer 9

Category C and are not indicated in pregnancy, or for breastfeeding women or children me restore ovulation and women due to insulin resistance

Question 10

When in combination with insulin, T z d can cause…

Answer 10

Edema, fluid retention, heart failure

Question 11

Describe effects that T z d can have on weight

Answer 11

Combination of fluid retention and subcutaneous fat accumulation can cause weight gain

Question 12

Describe the difference in lipid panel between Actos and Avandia

Answer 12

Actos can elevate HDL cholesterol, Avandia can increase HDL and LDL cholesterol

Question 13

Tzd should be used with caution in what patients

Answer 13

Hepatic dysfunction because it can elevate hepatic enzyme

Question 14

T z d contraindications

Answer 14

Heart failure, liver disease