Amylin analog

Question 1

What drug is an amylin analog?

Answer 1

Pramlinitide (symlin)

Question 2

How does amylin work naturally in the body?

Answer 2

Produced and co secreted with insulin in response to food intake

Question 3

How does amylin work in type 1 and tyoe 2 diabetics?

Answer 3

T1 and t2 dm whi require insulin, amylin is dimished d/t pancreatic beta cell dysfunction

Question 4

Details of pramlintide (symlin) for t1 dm?

Answer 4

15-60 mcg before meals

Titrate up 15 mcg until nausea tolerated

Question 5

Details of pramlintide (symlin) for t2dm?

Answer 5

60-120 mcg before meals

Question 6

Why does amylin help lower bg?

Answer 6

Decreases side of post meal bg by:
Slowing gastic emptying
Supressing glucagon
Reducing total caloric intake
Increased satiety

Question 7

Is symlin injection or pill?

Answer 7

Injection

Question 8

What other med can you take if you are t2 dm??

Answer 8

Sulf met

Question 9

Mist this be given alongside insulin?

Answer 9

Yes

Question 10

Can symlin be mixed with insulin?

Answer 10

Never

Question 11

Symlin duration of action

Answer 11

Half life 48 minutes to 3 hour duration after injection

Question 12

Where is symlin metabolized

Answer 12

Kidney

Kidney failure doesny alter clearance

Question 13

Why can symlin cause hypo

Answer 13

Secondary effect of making insulin more effective

Question 14

Descrive gi effects of symlin

Answer 14

Gastroparesis d/t slow hastric emptying.

This means symlin should not be taken with alpha glucosidase inhibitors or anticholinergic agents

Question 15

Biggest side effect

Answer 15

Nauses
48%
Decreases with time
Need fradual titration
Anorecia, vomit, fatigue, headache