GLP 1 Flashcards
How do incretin based therapies work?
Following a meal, gut hormones are released causing:
1) promption of satiety on brain
2) slow gastric emptying
3) increased insulin realse from beta cella
4) decreased glucagon release from alpha cells
What gut hormones are released when you eat?
GIP- glucose dependent insulinotropic peptide
GLP1- glucagon like peptide 1
How long does glp1 last before ddp4 inhibits it?
1-2 minutes
Name the glp1 receptor agonists
Extenatide (byetta or bydrueon)
Liraglutide (victoza)
Albiglutide (tanzeum)
Dulglutide (trulicity)
Exenatide (byetta) details
5-10 mcg
Twice daily
1 hour before meals
Liraglutide (victoza)
.6-1.8 mg increased by .6 weeklu
Once daily
Any time
Endogenously metabolized, no specific organ
Albiglutide (tanzeum)
30-50 mg
Once weekly
Dulglutide (trulicity)
.75-1.5 mg
Once weekly
Exenatide (bydureon)
2mg
Once weekly
Can you continue using other meds aith glp1?
Ges
Insulin, met, sulf
How us exenatide eliminated from the body?
Kidneys
Not recommended in severe renal impairment Cr
Shpuld caution be used with absorption of other meds?
Yes
Digoxin, lisinopril, lovastatin, acetaminophen
Thyroid cancer in glp1
Caution with byduroen, trulicitu, victoza tanzeum
Gl1p contraindications
Thyroid cancer
Gastic disease
T1dm dka
Side effecta
Nausea, vd, headache
