Sulfonylureas Flashcards
Do you need and endogenous insulin to use a sulf medication
Yes, sulfonylurea agents are useful only in patients who still produce endogenous insulin, they are exclusively for type 2 diabetics
Who is the typical candidate for a monotherapy with sulfonylurea
Type 2 diabetic without dyslipidemia who is not overweight
What is the mechanism of action for sulfonylurea
Increase the release of insulin from the pancreas by closing the energy sensitive potassium channel in the cell membrane of the beta cells which causes an increase in available insulin for action throughout the body
What two organs must you be cautious of when taking a sulfonylurea
Liver because that is where it is processed in metabolize, and renal
How do you do dose a sulfonylurea
Started at low doses and titrated as needed ranging from 1-8 milligrams daily
What are the names of the second generation sulfonylurea groups
Glimepiride (amaryl), glipizide (glucotrol), glyburide (diabeta, micronase)
What is the name for glimipiride
Amaryl
What is the name for glipizide
Glucotrol
What is the name for glyburide
Diabeta
Micronase
Glynase
How are sulfonylureas classified
category C, although wipe your eyes in retrospective studies although because many drugs are excreted in human milk so familiar areas should not be administered during nursing
Can you use sulfonylurea in children
Safety has not been established in children
Who should be monitored when taking a sulfonylurea
Elderly, debilitated, malnourished, adrenal pituitary or hepatic insufficiency, hypoglycemic patient
What are contraindications for sulfonylurea
Type 1 diabetics, ketoacidosis, allergy, hypersensitivity
What is the most common and serious adverse reaction to sulfonylurea
Hypoglycemia
What effects does sulfonylurea have on the blood sugars of the elderly
Progressive age related to clean and renal function alters drug clearance and predisposes a person to hypoglycemia
