Dpp4 inhibitors

Question 1

How does a dpp4 inhibitor med work

Answer 1

Inhibits enzyme that inactivates glp1

Prolong lofe of glp1 which increases insulin, reduces glucagon, slows hastric emptying, reduces food intake

Question 2

Name the two brand ddp4 drugs

Answer 2

Sitagliptin (januvia)

Saxagliptin (onglyza)

Question 3

Sitagliptin (januvia) details

Answer 3

100 mg daily

Once daily

Question 4

Saxagliptin (onglyza) details

Answer 4

2.5-5 mg daily

Once daily

Question 5

Which produces greater weight loss effects

Answer 5

Glp1

Question 6

Do you need food to take?

Answer 6

With or without

Question 7

What to do if patient has renal failure

Answer 7

Sitagliptin- reduces to 50 mg daily if Cr 30-50
Reduce to 25 if Cr less than 30
Saxagliptin- reduces to 2.5 if Cr

Question 8

Pregnancy?

Answer 8

Category B, no nursing

No studied in kids

Question 9

Combo of ddp4 inhibitors and sulf?

Answer 9

Sulf reduces to prevent hypos

Question 10

What effect can ddp4 inhibitors sitaglupin (januvia) have in pancread

Answer 10

Pancreatitis

Question 11

Side effects?

Answer 11

Serious allergic reaction (steven johnson, angioedema, anaphylaxis)
Hypersensitivity reactiona
Upper respiratory infection
Headache
Uti

Question 12

What should you monitor with increasing doses of sitagliptin (januvia)?

Answer 12

Pancreatitis

Question 13

Besides pancreatitis monitoring with januvia increase, what should be monitored with general ddp4 increase?

Answer 13

Kidney function, Cr