Thiazides and Sulfonamides

Question 1

What is the mechanism of action for thiaides and sulfonamides?

Answer 1

These diuretics work by blocking the descending convoluted tubule Na/Cl transporter blocking sodium and Cl reabsorption.

Question 2

What is the overall effect of Thiazides and Sulfonamides?

Answer 2

These medications work mostly to cause vasorelaxation and diuresis.

These also decrease calcium excretion.

Question 3

What is the most useful indication for thiazides and sulfonamides?

Answer 3

These are extremely cheap anti systemic arterial hypertension medications!

Also excellent in treating congestive heart failure edema.

Question 4

How do Thiazides and sulfonamides provide antihypertensive effects?

Answer 4

activation of Ca+ potassium channels leads to vasorelaxtion related total peripheral resistance aiding in antihypertensive properties.

Question 5

What are the adverse effects linked to thiazide and sulfonamide use?

Answer 5

Hypokalemia
Hyperglycemia
And
Hyperlipidemia (Except indapamaide)

Question 6

Which drugs should be avoided in Thiazide/sulfonamide use?

Answer 6

Digoxin (Increased toxicity due to hypokalemia)
and avoid in
Patients with Diabetes mellitus

Although its good for those with diabetes insipidus.

Question 7

Which diuretic is best if you want to avoid the formation of renal calcium stones?

Answer 7

The thiazides and sulfonamides.