Direct Renin Inhibitor Flashcards
1
Q
What is the name of the direct renin inhibitor?
A
Aliskiren
2
Q
How does the drug Aliskiren work?
A
This drug binds directly to renin preventing it from cleaving angiotensinogen to form ang I
3
Q
What medicinal purpose does Aliskiren have?
A
Lowers BP and is to be used for hypertension.
It does not however prevent CV events.
4
Q
What is the indication for Aliskiren?
A
Used for adjunctive therapy to lowering BP with thizaides, ACEi, ARBs, or CCBs,
5
Q
What are the side effects of Aliskiren?
A
Can cause hyperkalemia in patients with CKD and diabetes or in those receiving a potassium sparing diuretic.
6
Q
What is the contraindication to aliskiren use?
A
Pregnancy!
