ACEi

Question 1

What is the suffix of the ACEi?

Answer 1

All of them have the word “Pril” in the name.

Question 2

What is the MoA of ACEi?

Answer 2

These drugs inhibit the Angiotensin Convertig enzyme (ACE).
This decreases vasoconstriction, aldosterone production, and sodium/water retention.

Also leads to vasodilation by decreasing the breakdown of bradykinin and other vasoactive peptides.

Question 3

What two problems are ACEi first line treatments for?

Answer 3

These are add on agents for HTN and Diabetes

Question 4

What drug class are ACEi extremely synergistic with?

Answer 4

ACEi are synergistic with Diuretics!

Question 5

What is a complete and utter contraindication to ACEi use?

Answer 5

Pregnancy

as well as in bilateral renal artery stenosis and those with a history of angioedema

Question 6

How are most ACEi cleared from the body?

What are the two exceptions?

Answer 6

ACEi are cleared from the body by the kidney.

Fosinopril and Spirapril are both cleared equally by the liver and kidney.