thérapeutique Flashcards

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1
Q

thrombopénie induite à l’héparine type 2 grave

A

pic à 10jr
plaquette < 100.000 ou chute de plus de 40%
substitution par hirudine / danaparoide

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2
Q

si accident hémorragique par héparine

A

antidote : sulfate de protamine

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3
Q

INR = 3 - 4.5

A

prothèse valvulaire , FA sur RM

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4
Q

hge par surdosage aux avk

A

INR entre 4 et 6 = saut d’une prise
INR entre 6 et 10 = vit k 1 - 2 mg
INR plus de 10 hg grave = vit k 5 mg + ppsb / plasmaphérés , relais par héparine puis avk aprés 8j

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5
Q

atb sur BGN

A

amox + amp + glycopeptide +quinolone + polypeptide

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6
Q

atb à large spectre

A

bactrim + tétracycline + céphalosporine

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7
Q

ci de l’atropine

A

insuff cardiaque avec tachycardie
adénome de prostate
glaucome

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8
Q

effet secondaire radiothérapie

A
xérostomie
radiomucite
ostéoradionécrose mandibulaire
hypothyroidie
oedéme laryngé
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9
Q

vaccin vivant aténué

A
BRAVO
bcg
rotavirus
amarile ( fiévre jaune )
varicelle
ror
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10
Q

trt anticoagulant

A

prophylaxie primaire = prériop , alitement , valve cardiaque
prophylaxie secondaire = atcd m.thrombo embolique +anomalie de coagulation

HBPM = sc =
en préventif : TVP 1xpar jour , angor instable 2x/jr

HNF = sc(calcique) iv (sodique)

préventif = 150u ( 2 inj sc)

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11
Q

Thrombopénies induites par l’héparine

A

IgG dirigés contre des complexes Héparine-Facteur plaquettaire 4
type 1 =
Modéré = 2jr = aucune manif clinique = ne pas arréter le trt

TIH type 2 = Auto–immun
Brutale et profonde,plaq. . > 40 % = 5–12 jours = Thromboses veineuses&raquo_space;> art =
arréter trt

si atcd de TIH type 2 = on utilise = fondaparinux , danaparoide , lépirudine

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12
Q

intéraction avec AINS

A

sulfamide (augmente le risque d’hypoglycémie )

lithium/ digoxine / valproat = surdosage

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13
Q

contre indication BB

A

prinzmétal

AOMI

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14
Q

effets secondaires du Méthotrexate

A

Hépatite
Pneumopathie immuno-allergique
Cytopénie

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15
Q

chimiothérapie

A
cisplatine = ototoxicité  / néphrotox
cyclophosphamide = vessie
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