Theme 5 Quiz

Question 1

A premalignant change in cell proliferation and differentiation that is often associated with metaplasia (9)

Answer 1

dysplasia

Question 2

In some third world countries bladder cancer is associated with which parasitic disease? (15)

Answer 2

Schistosomiasis

Question 3

A key defining characteristic of malignant neoplasm (10)

Answer 3

metastasis

Question 4

** methyltransferase shows genetic variation in activity that can cause toxicity on treatment with some cytotoxic drugs. (10)

Answer 4

Thiopurine

Question 5

** syndrome = hereditary nonpolyposis colon cancer (HNPCC). (5)

Answer 5

Lynch

Question 6

A benign tumour of the meninges (10)

Answer 6

Meningioma

Question 7

** P450 oxidases are encoded by a family of genes and are responsible for metabolizingmany common drugs. (10)

Answer 7

Cytochrome

Question 8

term for X-inactivation in females, named after its discoverer. (11)

Answer 8

Lyonisation

Question 9

A modification to the genome that does not affect the nucleotide sequence. (10)

Answer 9

Epigenetic

Question 10

A targeted drug used in cases of breast cancer with HER2 amplification (9)

Answer 10

Herceptin

Question 11

The commonest type of cancer in men in UK (8)

Answer 11

Prostate

Question 12

Favoured site of haematogenous spread of tumour cells from primary lung and breast cancer (4)

Answer 12

Bone

Question 13

Benign tumour of striated muscle (11)

Answer 13

rhabdomyoma

Question 14

CpG **** is cluster of CG dinucleotides frequently found near the 5’ ends of genes. (6)

Answer 14

island

Question 15

Grade of tumour is a term that indicates its ____ (15)

Answer 15

differentiation

Question 16

Anticoagulant showing genetically-determined dosage sensitivity. (8)

Answer 16

Apixaban

Question 17

Uniparental ****: both copies of a chromosome from one parent. (6)

Answer 17

disomy

Question 18

Modifications to the tails of this class of proteins regulate gene expression. (7)

Answer 18

Histone

Question 19

Genetic deficiency of this enzyme can result in failure to recover from anaesthesia. (21)

Answer 19

Butyrylcholinesterase

Question 20

A serum marker used to screen for prostate cancer (3)

Answer 20

PSA

Question 21

These small regions are shared between the X and Y chromosomes. (15)

Answer 21

pseudoautosomal

Question 22

Genetic abnormality behind complete hydatidiform moles. (12)

Answer 22

androgenesis

Question 23

Asbestos is strongly linked to which highly malignant tumour? (12)

Answer 23

mesothelioma

Question 24

The frequency with which an inherited disorder manifests itself in gene carriers (10)

Answer 24

Penetrance

Question 25

A Dukes B tumour is distinguished from a Dukes A by virtue of the tumour having grown throughwhat structure? (6,5)

Answer 25

Muscle layer

Question 26

A malignant tumour of cartilage (14)

Answer 26

Chondrosarcoma

Question 27

Genes that are monoallelically expressed according to parent of origin are said to be *********. (9)

Answer 27

imprinted

Question 28

Overgrowth syndrome due to dysregulation of the IGF2 gene. (8)

Answer 28

beckwith

Question 29

Type of involuntary movement typical of Huntington’s disease. (6)

Answer 29

Chorea

Question 30

A defective Rb gene is inherited in which familial cancer syndrome? (14)

Answer 30

retinoblastoma

Question 31

Type of genetic diagnostic test performed on in vitro cultured embryo. (15)

Answer 31

Preimplantation

Question 32

A common type of tumour seen in patients with an inherited defect in the TP53 gene (7)

Answer 32

Sarcoma

Question 33

An angioma is a benign tumour of which tissue? (5,7)

Answer 33

Blood vessels

Question 34

Enzyme involved in the maintenance of repeat sequences at the ends of chromosomes (10)

Answer 34

Telomerase

Question 35

Most common pathway of metastatic spread of tumour cells (9)

Answer 35

Lymphatic

Question 36

Invasive method for obtaining tissue of fetal genotype for prenatal genetic diagnosis: ********* villussampling. (9)

Answer 36

Chorionic

Question 37

Common mechanism by which a proto-oncogene may become abnormally over-expressed (13)

Answer 37

Amplification