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EMS > Theme 5 Quiz > Flashcards

Theme 5 Quiz Flashcards

1
Q

A premalignant change in cell proliferation and differentiation that is often associated with metaplasia (9)

A

dysplasia

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2
Q

In some third world countries bladder cancer is associated with which parasitic disease? (15)

A

Schistosomiasis

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3
Q

A key defining characteristic of malignant neoplasm (10)

A

metastasis

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4
Q

** methyltransferase shows genetic variation in activity that can cause toxicity on treatment with some cytotoxic drugs. (10)

A

Thiopurine

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5
Q

** syndrome = hereditary nonpolyposis colon cancer (HNPCC). (5)

A

Lynch

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6
Q

A benign tumour of the meninges (10)

A

Meningioma

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7
Q

** P450 oxidases are encoded by a family of genes and are responsible for metabolizingmany common drugs. (10)

A

Cytochrome

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8
Q

term for X-inactivation in females, named after its discoverer. (11)

A

Lyonisation

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9
Q

A modification to the genome that does not affect the nucleotide sequence. (10)

A

Epigenetic

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10
Q

A targeted drug used in cases of breast cancer with HER2 amplification (9)

A

Herceptin

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11
Q

The commonest type of cancer in men in UK (8)

A

Prostate

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12
Q

Favoured site of haematogenous spread of tumour cells from primary lung and breast cancer (4)

A

Bone

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13
Q

Benign tumour of striated muscle (11)

A

rhabdomyoma

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14
Q

CpG **** is cluster of CG dinucleotides frequently found near the 5’ ends of genes. (6)

A

island

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15
Q

Grade of tumour is a term that indicates its ____ (15)

A

differentiation

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16
Q

Anticoagulant showing genetically-determined dosage sensitivity. (8)

A

Apixaban

17
Q

Uniparental ****: both copies of a chromosome from one parent. (6)

A

disomy

18
Q

Modifications to the tails of this class of proteins regulate gene expression. (7)

A

Histone

19
Q

Genetic deficiency of this enzyme can result in failure to recover from anaesthesia. (21)

A

Butyrylcholinesterase

20
Q

A serum marker used to screen for prostate cancer (3)

A

PSA

21
Q

These small regions are shared between the X and Y chromosomes. (15)

A

pseudoautosomal

22
Q

Genetic abnormality behind complete hydatidiform moles. (12)

A

androgenesis

23
Q

Asbestos is strongly linked to which highly malignant tumour? (12)

A

mesothelioma

24
Q

The frequency with which an inherited disorder manifests itself in gene carriers (10)

A

Penetrance

25
Q

A Dukes B tumour is distinguished from a Dukes A by virtue of the tumour having grown throughwhat structure? (6,5)

A

Muscle layer

26
Q

A malignant tumour of cartilage (14)

A

Chondrosarcoma

27
Q

Genes that are monoallelically expressed according to parent of origin are said to be *******. (9)

A

imprinted

28
Q

Overgrowth syndrome due to dysregulation of the IGF2 gene. (8)

A

beckwith

29
Q

Type of involuntary movement typical of Huntington’s disease. (6)

A

Chorea

30
Q

A defective Rb gene is inherited in which familial cancer syndrome? (14)

A

retinoblastoma

31
Q

Type of genetic diagnostic test performed on in vitro cultured embryo. (15)

A

Preimplantation

32
Q

A common type of tumour seen in patients with an inherited defect in the TP53 gene (7)

A

Sarcoma

33
Q

An angioma is a benign tumour of which tissue? (5,7)

A

Blood vessels

34
Q

Enzyme involved in the maintenance of repeat sequences at the ends of chromosomes (10)

A

Telomerase

35
Q

Most common pathway of metastatic spread of tumour cells (9)

A

Lymphatic

36
Q

Invasive method for obtaining tissue of fetal genotype for prenatal genetic diagnosis: ******* villussampling. (9)

A

Chorionic

37
Q

Common mechanism by which a proto-oncogene may become abnormally over-expressed (13)

A

Amplification

EMS (54 decks)

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