Theme 1 Quiz

Question 1

A suffix denoting dilatation

Answer 1

Ectasis

Question 2

Most common type of autopsy

Answer 2

Coroners

Question 3

A USA city whose name is given to a leukaemia-causing chromosomal rearrangement.

Answer 3

Philidelphia

Question 4

A reduction in the number of blood cells

Answer 4

Cytopenia

Question 5

Okazaki fragments take part in which process to do with DNA?

Answer 5

Replication

Question 6

The sequencing technology used in the human genome mapping project

Answer 6

Sanger

Question 7

A unit of chromatin, comprising about 200 bp of DNA wound around a histone core

Answer 7

Nucleosome

Question 8

What does the “ectasis” in bronchiectasis mean?

Answer 8

Dilation

Question 9

That part of a gene whose sequence is represented in the mature mRNA

Answer 9

Exon

Question 10

A subtype of B cell that are formed within germinal centre following primary infection and can survive for decades and repeatedly generate an accelerated and robust antibody-mediated immune response

Answer 10

Memory

Question 11

The abnormal development or degeneration of a tissue

Question 12

The traditional method of studying large scale genome pathology such as translocation, gene duplication etc by examining the complete set of metaphase chromosomes using G-banding.

Answer 12

Karyotyping

Question 13

An individual version or genetic variant at a particular locus.

Answer 13

allele

Question 14

A genetic change

Answer 14

Mutation

Question 15

Category of death that must be reported to the coroner

Answer 15

unnatural

Question 16

An organism that is a common cause of prosthetic joint infection

Answer 16

staphylococcus epidermiidis

Question 17

Mechanisms through which the aetiology of a disease produces its clinicopathological effects

Answer 17

Pathogenesis

Question 18

This term is used to refer to increasing severity of an inherited disease as it passes down successive generations.

Answer 18

Anticipation

Question 19

A malignant epithelial tumour

Answer 19

Carcinoma

Question 20

An evolutionary remnant, in the form of a DNA sequence that resembles a gene elsewhere in the genome, but has mutations that appear to render it inactive.

Answer 20

Pseudogene

Question 21

Aetiology is the study of what aspect of disease?

Answer 21

Cause

Question 22

Vertical (parent to child) inheritance of a disorder is typically seen for autosomal ——– conditions

Answer 22

Dominant

Question 23

An aspect of family structure that increases the risk of autosomal recessive disease.

Answer 23

Consanguinity

Question 24

What is the study of the incidence and population distribution of disease called?

Answer 24

Epidemiology

Question 25

A term used to describe how a genetic change manifests itself.

Answer 25

Phenotype

Question 26

Shape of the mitochondrial genome

Answer 26

circular

Question 27

A condition that is encountered by the haematologist where the patients could present with bleeding into joints

Answer 27

haemophilia

Question 28

This region of the chromosome separates the short and long arms

Answer 28

Centromere