Lecture 26: Immunopathology Hypersensitivity Flashcards
1
Q
What is an allergy?
A
A reaction produced by the normal immune system (directed against innocuous antigens) in a pre-sensitized (immune)host.
2
Q
Who invested the immunopathological classification of hypersensitivity?
A
Coombs & Gell 1963
3
Q
What is the immunopathogenesis of type 1 hypersensitivity?
A
IgE antibody mediated mast cell and basophil degranulation
Release of preformed and de novo synthesized inflammatory mediators
4
Q
What are the clinical features of type 1 hypersensitivity?
A
- Fast onset (15-30 min)
- Wheal and flare
5
Q
What is involved in the late phase response for type 1 hypersensitivity?
A
- Eosinophils
- Central role for Th2 T cell
6
Q
What is involved in the primary response of Type 1 hypersensitivity?
A
