The senses Flashcards

1
Q

Cutaneous Receptors

A

for touch

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2
Q

nociceptors

A

These are specialized sensory neurons that detect painful stimuli

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3
Q

Somatosensation

A

sensation is split into consius and uncounsous

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4
Q

concuss

A

proprioception and exteroception

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5
Q

uncoutious

A

enteroception and proprioception

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6
Q

what are the receptors

A

o Mechanoreceptors
Cutaneous,
Proprioception, force
o Thermoreceptors
Temperature
o Nociceptors
Pain

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7
Q

Merkel cells

A

found om glamorous or hairless skin, detect light touch and PRESSURE

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8
Q

where can these receptors be found?

A
  1. Skin
    Tactile, thermoreceptors, pain
  2. Muscle
    Muscle spindle
  3. Joints
    Articular
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9
Q

there was a diagram provides and from this cells were identified- A Merkel disc

A

A merkel disc consistes of

Merkel Cell – A modified epithelial cell that detects mechanical stimuli.

Afferent Nerve Ending – A sensory nerve fiber that transmits signals to the central nervous system.

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10
Q

Meissner’s Corpuscles

A

Meissner’s corpuscles are specialized mechanoreceptors found in the glabrous (hairless) skin that detect light touch and low-frequency vibrations.- made of stacked swhannn cells

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11
Q

Pacinian corpuscles

A

are specialized mechanoreceptors that detect deep pressure and high-frequency vibrations.

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12
Q

Ruffini endings

A

are specialized mechanoreceptors that detect skin stretch and sustained pressure.

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13
Q

Merkel Discs (Merkel Cells) are what kind of adapting?

A

slow adapting

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14
Q

Ruffini Endings are what kind of adapting

A

slowly adapting

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15
Q

what kind of adapting is messiniers courpsule

A

rapidly adapting

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16
Q

Meissner’s corpuscles are located where?

A

located in hands/feet
touch, vibration (5-50 Hz)
rapidly adapting

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17
Q

what about Pacinian Corpuscles what do they do?

A

high frequency vibration (300 Hz)
rapidly adapting

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18
Q

what is the difference between messiners corpuscles and Pacinian corpuscles?

A

Massiners are 0.5-1 mm
deep
Pacinians are 2- 3 mm deep

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19
Q

What is the two point discrimination test

A

The ability to distinguish between two
stimuli that are applied at close distances.
This varies in different parts of the body.

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20
Q

where is the most sensitive place on the body for the two point test?

A

Palms of the hands and
face

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21
Q

how do we know that the hand is sensitive?

A

250,000 nerve fibers to
mechanoreceptors; 17,000 of these in the hand

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22
Q

what is an important feature of cutaneous receptors?

A

Cutaneous input from the feet has an
important role in posture and balance

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23
Q

why is the back less sensitive to water droplets?

A

On limbs (except palms) and body wall
the receptive fields of Pacinian and Ruffini endings are very large.

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24
Q

what types of hairs receive responses?

A

o-hairs and D-hairs

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25
The hairs of the body are what?
rapidly adapting and low threshold
26
What are C fibres LTMs
For Touch , slow adapting and low threshold for pleasant contact
27
what are machanico-noiceptors polymodal noichiceptoers
they are used for injurious force Slow adapting , High thereshold
28
what is important about motor neurons?
only nerve fibers from muscle spindles (1a afferents) synapse directly with motoneurons
29
what is the Descending Corticospinal Pathway
The corticospinal pathway carries the motor commands from the motor cortex to the muscles needed for the grip.
30
during grip what sends feedback about muscle strength?
Muscle Spindles and Golgi Tendon Organs in the muscles provide feedback about the muscle length and tension
31
Ascending Lemniscal Pathway
The lemniscal pathway carries information to brain about touch, pressure, and proprioception (the sense of where your hand is in space).
32
the adjustment for grip strength is done by what?
Based on this feedback, the brain sends adjustment signals back through the motor cortex, via the corticospinal pathway, to fine-tune the grip
33
what is the somatosensory cortex?
where the brain processes the sensory input (e.g., texture, pressure, and proprioception).
34
How the Thalamus Works in Sensory Processing?
When sensory information (e.g., touch, temperature, pressure) is gathered from receptors in the skin or muscles, it travels up the spinal cord. The thalamus, located in the brainstem, acts as a relay station that filters and relays the sensory signals to the somatosensory cortex in the parietal lobe of the brain.
35
Brodmann Areas
Area 3,1,2 : Primary Somatosensory cortex Area 4: Primary Motor Cortex
36
what did Wilder Penfield do?
Penfield's most famous achievement was creating a map of the somatosensory and motor cortices of the brain, called the "motor homunculus" and "sensory homunculus"
37
what happens to Cortical representation throughout life? Why is it deemed static?
Is not static through life but modifiable through changing input and learning
38
merizech
He is particularly known for his groundbreaking work on how the brain is capable of reorganizing itself.Progressive change in cortical representation after transection of the median nerve
39
Sensory cancellation of tactile sensation
the brain suppresses some information in order to focus on other stimuli or avoid overwhelming sensory information eg Humans: Why can’t we tickle ourselves? Brain cancels out predictable touches
40
coronary discharge
When you move your eyes or head, the image on your retina changes. To keep your vision stable, your brain sends a signal (corollary discharge) that tells your visual system, “Hey, this movement is coming from me!” This prevents you from feeling like everything is shifting around randomly. It's like the brain is saying, "I moved, so the shift in what I see is normal, not something that should surprise me."
41
what is the primary endings
Primary endings are type Ia afferent fibers that wrap around the central part of the muscle spindle fibers. They are responsible for detecting changes in muscle length and how fast those changes are happening.
42
Ia Afferent
Ia afferent fibers carry sensory information from muscle spindles to the brain, specifically about how much a muscle is stretched and how fast it's changing
43
Alpha motor neurons
Are a crucial part of the nervous system that are responsible for controlling voluntary muscle contraction.
44
gamma motor neurones
are a crucial part of the nervous system that are responsible for controlling voluntary muscle contraction.
45
The sensory-motor system is a critical part of the nervous system
that integrates sensory input (information from the environment and body) and translates it into motor output (muscle movements).
46
Cortical areas:
Primary motor cortex M1 Premotor cortex Supplementary motor area S-I and S-II PPC
47
Sub-cortical areas:
Cerebellum Basal Ganglia
48
Main Descending Motor Pathways:
Corticospinal Tract (Pyramidal Tract), Extrapyramidal Tracts, Rubrospinal Tract, Reticulospinal Tract,
49
Outline Rubrospinal Tract:
Origin: The red nucleus in the midbrain. Function: It plays a role in controlling muscle tone and coordination of limb movements, especially in the upper limbs. Decussation: It crosses over in the midbrain
50
Vestibulospinal
Vestibulospinal Tract: Origin: The vestibular nuclei in the medulla (brainstem). Function: This pathway is important for maintaining balance and posture. It helps coordinate movements that keep the body upright, especially in response to changes in head position (like when you're balancing or walking). Decussation: The lateral vestibulospinal tract does not cross (uncrossed), while the medial vestibulospinal tract does cross over at the level of the brainstem.
51
Tectospinal Tract:
Origin: The superior colliculus (a part of the midbrain involved in visual processing). Function: It helps coordinate movements in response to visual stimuli, especially head and neck movements in response to visual cues (like turning your head to look at something). Decussation: It crosses over at the level of the midbrain
52
Motor Prediction: predicting our actions
The ability of the CNS to anticipate the consequences of action is critical for the control of voluntary action
53
what are Command neurons?
Term introduced by Wiersma (1964), When stimulated these neurons evoked a movement, the pattern of which was NOT coded in their sequence of spikes Neural decision-making cells
54
what ones are involved in forward prediction?
Prefrontal Cortex (PFC), Motor cortex, cerebellum
55
Command neurons in the mouse
Brainstem neurons were found to be responsible for stopping locomotion * The neurons could ‘command’ the rhythmic neural circuits (the CPG) to stop locomotion
56
the neurogenerative disseises effect what?
the basal ganglia
57
what si the basal ganglia?
Brainstem neurons were found to be responsible for stopping locomotion * The neurons could ‘command’ the rhythmic neural circuits (the CPG) to stop locomotion
58
Cortico-basal-thalamocortical loops: the motor loop
motor cortex--> patamen--> lateral GPi ---> ventral lateral neuculas
59
Executive loop
Dorsolateral prefrountal cortex ---> Dorsolateral coaudate ----> Medial GPi ---> medial dorsal and ventral anterior neucai
60
limbic loop
Anterior cingulate cortex ---> ventral striatum ---> ventral pallidum ----> medial dorsal nucleas
61
describe the basal ganglia motor loop?
Results in the activation of the supplementary motor area (SMA) before and during movement. * SMA activity prior to movement: the ‘readiness potential’ * Function: sequencing of serial order actions for the execution of learned motor programs. * Direct and Indirect pathways: Go v No Go
62
The Direct Pathway: Go
excites the motor cortex, 5 neurons- 1. Corticostriate fibres from sensorimotor cortex activate GABAergic spiny neurons in the striatum with D1 class dopamine receptors. These neurons are receiving nigrostriatal input 2. Activated GABAergic striatal neurons inhibit internal pallidal GPi neurons 4. Activation of the supplementary motor area (SMA) 5. Modification of corticostriate activity and initiation of movement via corticospinal (CST) and corticoreticulospinal tracts (CRT)
63
Indirect Pathway ‘no go’
7 neurons 1. Corticostriate fibres from sensorimotor cortex activate GABAergic spiny neurons in the striatum with D2 class dopamine receptors. These neurons are receiving nigrostriatal input. 2. Activated striatal neurons inhibit external pallidal GPe neurons. 3. The subthalamic nucleus (STN) receives input from the GPe neurons 4. The STN excites the internal pallidal neurons (GPi) 5. Inhibition of ventral lateral nucleus (VLN) thalamocortical neurons 6. Activation of the SMA (reduced due to 5) 7. Modification of corticostriate activity and initiation of movement via corticospinal (CST) and corticoreticulospinal tracts (CRT)
64
Parkinson’s Disease Symptoms - Tremor:
dysfunction in 2 circuits the basal ganglia and the cerebello-thalamo-cortical pathway
65
Rigidity:
Lead Pipe’ rigidity, Co-contraction of prime movers and agonists, dysfunction related to golgi tendon organs (1b) autogenic inhibition
66
Akinesia/Bradykinesia:
Weakened contribution of the SMA prior to movement
67
Posture:
Impaired in anticipatory postural adjustments
68
How is movement sculpted?
Basal Ganglia direct and indirect pathways compete to either facilitate or inhibit movement * Disinhibition of the thalamus (Direct pathway) is opposed by inhibition of the thalamus by additional excitatory circuitry from the STN to the GPi)
69
movement is then explained as how Parkinson’s Disease and Huntington’s Chorea
chorea- excessive movements- Overactivity of the Direct Pathway Parkinson's disease-Overactivity of the Indirect Pathway
70
mirror neurons
Mirror neurons are a special type of brain cell that fires both when you perform an action and when you observe someone else performing the same action. This means that the same neural circuits are active whether you're doing something yourself or just watching another person do it.
71