colm Cunningham immune Flashcards

immune- 1 lecture

1
Q

what are the things that the immune system must fight against?

A

cancer, viruses and bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

where do the immune cells begin?

A

bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

then where do they mature?

A

Thymus (T cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

how do they then travel around the body?

A

endothelium similar to blood vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are peyers patches

A

Peyer’s Patches are small clusters of lymphoid tissue (part of the immune system) found in the walls of the small intestine, mainly in the ileum (the last part of the small intestine).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are the innate immune cells?

A

Dendritic cells, neutrophil,Macrophage ,Natural killer cell,Eodsionphil ,Basophil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are the adaptive immunes cells?

A

B cell and T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

recently a new class of immune cells was found- what are they.

A

γδ T Cells (Gamma Delta T Cells) and NkT cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what do γδ T Cells (Gamma Delta T Cells) do?

A

Bridge innate and adaptive immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what do the NkT cells do

A

NKT cells are a unique hybrid of T cells and Natural Killer (NK) cells, playing a special role in the immune system. They act as a bridge between innate and adaptive immunity.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

there is a balence of the immune system what are they

A

immune over reaction, and immune under reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

an imunne over reaction - internal thereat examples

A

Lupus and Type 1 diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

External threat immune over reaction

A

allergic responses eg asthema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

immune under reaction, disease examples

A

HIV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

immune under reaction infection

A

mold and fungus, parasites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Homeostatic Inflammation

A

healthy state- Transient inflammation, progressive inflammation, pathogenic inflammation then disease.

17
Q

RNA viruses are recognised by what?

A

via nucleic acid
detection and drive Interferons

18
Q

viruses will always try to prevent and subvert- how do they do this?

A

by editing their structure- for example CovNSP15

19
Q

SARS-COV-1PLP

A

removes ubiquinone’s which mark the virus for degradation by the proteasome

20
Q

Viral Sepsis &
Systemic inflammation eg Infection of lung epithelium

A

Increased Vascular permeability
& local inflammation
Lung function & Hypoxemia
Acute anti-viral response
‘goes systemic’
Increased coagulation-(blood clotting throughout the body)
Microcirculation problems
brain tissue hypoxia

21
Q

the term going systemic means

A

This overwhelming response can cause systemic vasodilation, vascular leakage, and multi-organ dysfunction.

The immune system’s response “goes systemic”, causing widespread tissue damage, and hypoxia in various organs, not just the lungs.

22
Q

Autocrine signalling example

A

T cell cytokine interleukin-2 (IL-2)-
This triggers IL-2 release by T cell
(an inter-leukin – between leukocytes)
This IL-2 binds T cell IL-2R (autocrine)
stimulates proliferation of this antigenspecific T cell clone

23
Q

Name the two process signalling -

A

Signal 1: TCR (T-cell Receptor) Recognition
The T-cell receptor (TCR) on the surface of a CD4+ T cell or CD8+ T cell recognizes and binds to the MHC-peptide complex on the surface of an antigen-presenting cell (APC).

signal 2: The second signal comes from a co-stimulatory interaction. In this case, the CD28 receptor on the T-cell binds to the B7 family of molecules (often CD80 or CD86) expressed on the APC. This provides the necessary second signal for full T-cell activation

24
Q

What is CTLA-4?

A

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is a critical immune checkpoint molecule that plays an important role in regulating the immune response, particularly in T-cell activation. CTLA4/PD1
compete with
CD28 for B7

25
Q

what does illitimumab

A

blocks CTLA4 for immune response to proceed

26
Q

what is then the second checkpoint-

A

Nivolumab-blocks PD1

27
Q

inflammation and obesity-

A

fat tissue contains 50-60% macrophages and T-cells. - Macrophages in adipose tissue become pro-inflammatory, secreting cytokines such as TNF-α, IL-6, and IL-1β, which contribute to systemic inflammation and impair insulin signaling, leading to insulin resistance.

28
Q

lean tissues do what? -

A

adipokines -leptin

29
Q

obese adipose tissue lets off what?

A

proinflammatory molecules -IL6 , NO

30
Q

Invariant natural killer T cells (iNKT)

A

restricted and conserved CDR3 region,
non-MHC- restricted - They do not require the traditional antigen presentation by MHC molecules like conventional T cells, allowing them to respond more swiftly.
semi-invariant- alpha chains of all are identical
work to remove senescent cells- recognise lipid antigens

31
Q

what is the problem with obsesy-

A

iNKT Cells are Enriched in Visceral Fat But are Depleted in Obesity

32
Q

iNKT cells secrete what?

A

IL-10 is an anti-inflammatory cytokine that plays a crucial role in immune regulation. Here’s a breakdown of how iNKT cells producing IL-10 fits into their broader functions:

33
Q

a rare feature of INKT cells

A

they regulate metabolism and even help to keep us warm.

34
Q

the brain layers are in the order-

A

meninges-
Dura
Arachoid
subarachnoid space
Pia

35
Q

Microglia

A

are specialized immune cells in the central nervous system (CNS).

36
Q

what does the TREM2 pathway do?

A

TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) is a receptor that plays a crucial role in regulating the activity of microglia and other myeloid cells.