colm Cunningham immune Flashcards
immune- 1 lecture
what are the things that the immune system must fight against?
cancer, viruses and bacteria
where do the immune cells begin?
bone marrow
then where do they mature?
Thymus (T cells)
how do they then travel around the body?
endothelium similar to blood vessels
what are peyers patches
Peyer’s Patches are small clusters of lymphoid tissue (part of the immune system) found in the walls of the small intestine, mainly in the ileum (the last part of the small intestine).
what are the innate immune cells?
Dendritic cells, neutrophil,Macrophage ,Natural killer cell,Eodsionphil ,Basophil
what are the adaptive immunes cells?
B cell and T cells
recently a new class of immune cells was found- what are they.
γδ T Cells (Gamma Delta T Cells) and NkT cells
what do γδ T Cells (Gamma Delta T Cells) do?
Bridge innate and adaptive immunity
what do the NkT cells do
NKT cells are a unique hybrid of T cells and Natural Killer (NK) cells, playing a special role in the immune system. They act as a bridge between innate and adaptive immunity.
there is a balence of the immune system what are they
immune over reaction, and immune under reaction
an imunne over reaction - internal thereat examples
Lupus and Type 1 diabetes
External threat immune over reaction
allergic responses eg asthema
immune under reaction, disease examples
HIV
immune under reaction infection
mold and fungus, parasites
Homeostatic Inflammation
healthy state- Transient inflammation, progressive inflammation, pathogenic inflammation then disease.
RNA viruses are recognised by what?
via nucleic acid
detection and drive Interferons
viruses will always try to prevent and subvert- how do they do this?
by editing their structure- for example CovNSP15
SARS-COV-1PLP
removes ubiquinone’s which mark the virus for degradation by the proteasome
Viral Sepsis &
Systemic inflammation eg Infection of lung epithelium
Increased Vascular permeability
& local inflammation
Lung function & Hypoxemia
Acute anti-viral response
‘goes systemic’
Increased coagulation-(blood clotting throughout the body)
Microcirculation problems
brain tissue hypoxia
the term going systemic means
This overwhelming response can cause systemic vasodilation, vascular leakage, and multi-organ dysfunction.
The immune system’s response “goes systemic”, causing widespread tissue damage, and hypoxia in various organs, not just the lungs.
Autocrine signalling example
T cell cytokine interleukin-2 (IL-2)-
This triggers IL-2 release by T cell
(an inter-leukin – between leukocytes)
This IL-2 binds T cell IL-2R (autocrine)
stimulates proliferation of this antigenspecific T cell clone
Name the two process signalling -
Signal 1: TCR (T-cell Receptor) Recognition
The T-cell receptor (TCR) on the surface of a CD4+ T cell or CD8+ T cell recognizes and binds to the MHC-peptide complex on the surface of an antigen-presenting cell (APC).
signal 2: The second signal comes from a co-stimulatory interaction. In this case, the CD28 receptor on the T-cell binds to the B7 family of molecules (often CD80 or CD86) expressed on the APC. This provides the necessary second signal for full T-cell activation
What is CTLA-4?
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is a critical immune checkpoint molecule that plays an important role in regulating the immune response, particularly in T-cell activation. CTLA4/PD1
compete with
CD28 for B7
what does illitimumab
blocks CTLA4 for immune response to proceed
what is then the second checkpoint-
Nivolumab-blocks PD1
inflammation and obesity-
fat tissue contains 50-60% macrophages and T-cells. - Macrophages in adipose tissue become pro-inflammatory, secreting cytokines such as TNF-α, IL-6, and IL-1β, which contribute to systemic inflammation and impair insulin signaling, leading to insulin resistance.
lean tissues do what? -
adipokines -leptin
obese adipose tissue lets off what?
proinflammatory molecules -IL6 , NO
Invariant natural killer T cells (iNKT)
restricted and conserved CDR3 region,
non-MHC- restricted - They do not require the traditional antigen presentation by MHC molecules like conventional T cells, allowing them to respond more swiftly.
semi-invariant- alpha chains of all are identical
work to remove senescent cells- recognise lipid antigens
what is the problem with obsesy-
iNKT Cells are Enriched in Visceral Fat But are Depleted in Obesity
iNKT cells secrete what?
IL-10 is an anti-inflammatory cytokine that plays a crucial role in immune regulation. Here’s a breakdown of how iNKT cells producing IL-10 fits into their broader functions:
a rare feature of INKT cells
they regulate metabolism and even help to keep us warm.
the brain layers are in the order-
meninges-
Dura
Arachoid
subarachnoid space
Pia
Microglia
are specialized immune cells in the central nervous system (CNS).
what does the TREM2 pathway do?
TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) is a receptor that plays a crucial role in regulating the activity of microglia and other myeloid cells.