The pituitary gland clinical case Flashcards
hypersecretion of GH from a pituitary tumour is likely to lead to…..
acromegaly
hypersecretion of ACTH from a pituitary tumour is likely to lead to…..
cushings disease
hypersecretion of prolactin from a pituitary tumour is likely to lead to…..
hyperpolactinaemia
clinical features of acromegaly
wide hands and feet
coarse facial features
thick lips and tongue
carpal tunnel syndrome
sweating
thinning teeth
complications of having acromegaly
headache
chiasm compression
diabetes
hypertension
cardiomyopathy
sleep apnoea
colonic polyps
Tests you can do to diagnose acromegaly
GH test (pituitary function tests)
insulin like growth factor 1 tests
management of acromegaly includes
GH receptor antagonists
somatostatin analogues
surgery/radiotherapy
cushings syndrome occurs due to an excess of what?
cortisol
high value diagnostic symptoms of cushing’s syndrome include
skin atrophy
proximal myopathy
osteoporosis
growth arrest in children
cushing’s syndrome ACTH dependent causes are… (2)
pituitary tumour
ectopic ACTH secretion
cushing’s syndrome ACTH independent causes are… (2)
adrenal tumour
corticosteroid therapy
Hyperprolactinaemia physiological causes (3)
pregnancy
lactation
stress
Hyperprolactinaemia pharmacological causes (2)
DA depleting
DA antagonist drugs
Hyperprolactinaemia pathological causes (2)
primary hypothyroidism
pituitary lesions
clinical manifestations of Hyperprolactinaemia in women
menstrual irregularity
infertility
clinical manifestations of Hyperprolactinaemia in men
impotence
visual field abnormalities
headache
muscle weakness
Drugs which may cause hyperprolactinaemia
Dopamine antagonists
DA depleting agents
oestrogen
some antidepressants
clinical features of hypopituitarism in children
reduced linear growth
delayed puberty
clinical features of hypopituitarism in adults
tiredness, weight gain, depression, reduced libido, impotence
skin pallor
reduced body hair
Cranial Diabetes Insipidus can be tested by the
Water Deprivation Test
Cranial diabetes insipidus differential diagnosis
idiopathic
post trauma
metastatic carcinoma
other brain tumours
