The pituitary gland clinical case

Question 1

hypersecretion of GH from a pituitary tumour is likely to lead to…..

Answer 1

acromegaly

Question 2

hypersecretion of ACTH from a pituitary tumour is likely to lead to…..

Answer 2

cushings disease

Question 3

hypersecretion of prolactin from a pituitary tumour is likely to lead to…..

Answer 3

hyperpolactinaemia

Question 4

clinical features of acromegaly

Answer 4

wide hands and feet

coarse facial features

thick lips and tongue

carpal tunnel syndrome

sweating

thinning teeth

Question 5

complications of having acromegaly

Answer 5

headache

chiasm compression

diabetes

hypertension

cardiomyopathy

sleep apnoea

colonic polyps

Question 6

Tests you can do to diagnose acromegaly

Answer 6

GH test (pituitary function tests)

insulin like growth factor 1 tests

Question 7

management of acromegaly includes

Answer 7

GH receptor antagonists

somatostatin analogues

surgery/radiotherapy

Question 8

cushings syndrome occurs due to an excess of what?

Answer 8

cortisol

Question 9

high value diagnostic symptoms of cushing’s syndrome include

Answer 9

skin atrophy

proximal myopathy

osteoporosis

growth arrest in children

Question 10

cushing’s syndrome ACTH dependent causes are… (2)

Answer 10

pituitary tumour

ectopic ACTH secretion

Question 11

cushing’s syndrome ACTH independent causes are… (2)

Answer 11

adrenal tumour

corticosteroid therapy

Question 12

Hyperprolactinaemia physiological causes (3)

Answer 12

pregnancy

lactation

stress

Question 13

Hyperprolactinaemia pharmacological causes (2)

Answer 13

DA depleting

DA antagonist drugs

Question 14

Hyperprolactinaemia pathological causes (2)

Answer 14

primary hypothyroidism

pituitary lesions

Question 15

clinical manifestations of Hyperprolactinaemia in women

Answer 15

menstrual irregularity

infertility

Question 16

clinical manifestations of Hyperprolactinaemia in men

Answer 16

impotence

visual field abnormalities

headache

muscle weakness

Question 17

Drugs which may cause hyperprolactinaemia

Answer 17

Dopamine antagonists

DA depleting agents

oestrogen

some antidepressants

Question 18

clinical features of hypopituitarism in children

Answer 18

reduced linear growth

delayed puberty

Question 19

clinical features of hypopituitarism in adults

Answer 19

tiredness, weight gain, depression, reduced libido, impotence

skin pallor

reduced body hair

Question 20

Cranial Diabetes Insipidus can be tested by the

Answer 20

Water Deprivation Test

Question 21

Cranial diabetes insipidus differential diagnosis

Answer 21

idiopathic

post trauma

metastatic carcinoma

other brain tumours