Immunology of endocrine (finish when revising) disease Flashcards
Are autoimmune diseases more common in males or females?
females
What autoimmune disorder would result from attacking the self-antigen ACH receptor?
Myasthenia Gravis
What autoimmune disorder would result from attacking the self-antigen TSH receptor?
hypo or hyperthyroidism
tolerogens
antigens that induce tolerance
What type of diabetes is insulin dependent?
T1DM
What do delta cells in the islets of langerhans secrete?
somatostatin (GHIH)
What do beta cells in the islets of langerhans secrete?
insulin
What do alpha cells in the islets of langerhans secrete?
glucagon
causes of T1DM
viral infections
genetic factor
autoimmune
What type of diabetes involves the lymphocytic infiltration of islet of langerhans with specific destruction of beta cells?
T1DM
suspected diabetes:
normal or high insulin levels.
What type of diabetes do they have?
T2DM
Juvenile onset diabetes
type 1
Thyroid gland:
What lines their cuboidal cells?
follicles
hyperthyroidism 3 main causes:
graves disease
functioning adenoma
toxic multi nodular goitre
most common cause of thyrotoxicosis
graves disease
LATS are common in
graves disease
what are LATS?
long acting thyroid stimulating immunoglobulins
most common cause of hypothyroidism
hashimoto’s thyroiditis
cretinism can be a result of what?
congenital hypothyroidism
