The Human Genome Project Flashcards
How were BACs (bacterial artificial chromosome) were used in the Human Genome Project?
To hold fragments on genomic DNA as part of the physical mapping process
What are LD (linkage disequilibrium) clocks made up of
Haplotypes, which are combinations of alleles at multiple loci that tend to be inherited together.
Are LD blocks regions where there’s high or low meiotic crossover?
Low crossover, meaning the alleles in these regions tend to be inherited together rather than recombining frequently.
What can population genetics help identify?
Genomic regions subject to recent natural selection, helping to understand how certain genes evolve in response to environmental pressures.
How does population genetics contribute to personalised medicine?
Guide the use of correct drug treatments and doses for appropriate patients, based on genetic variations that affect drug metabolism.
What aspect of human history can population genetics help describe?
Prehistoric migration and origin of human groups by studying the genetic diversity within populations and tracing ancestry.
How can population genetics improve patient safety with medications?
Ensuring certain medications do not cause harmful side effects by identifying genetic variants that affect drug response.
What project identified millions of single nucleotide polymorphisms (SNPs) in many ethnic groups across the World
International HapMap project
