Epigenetics

Question 1

What term describes a loosely packed form of chromatin associated with active gene expression (transcription)?

Answer 1

Euchromatin

Question 2

What term describes a tightly packed form of chromatin associated with being genetically inactive

Answer 2

Heterochromatin

Question 3

In which region of a gene is there an enrichment of CpG sequences (CpG islands)?

Answer 3

Promoter regions

Question 4

“Modifications to the genome that affect gene expression but do not alter the DNA sequence” describes what?

Answer 4

Epigenetics

Question 5

Are epigenetic changes reversible or irreversible?

Answer 5

Reversible

Question 6

Regions of DNA rich in cytosine and guanine nucleotides are referred to as what?

Answer 6

CpG islands

Question 7

Methyl binding proteins bind to methylated DNA which prevents binding of transcription factors. What does this alter?

Answer 7

Gene expression

Question 8

DNA is packed with proteins called histones. What is the overall DNA-histone complex referred to as?

Answer 8

Chromatin

Question 9

Epigenetic and histone changes can be linked to what disease?

Answer 9

Cancer

Question 10

How are CpG islands methylated?

Answer 10

Through the addition of methyl groups to cytosine bases

Question 11

What are nucleosomes?

Answer 11

DNA tightly wound round histones.