Cell Death Flashcards
1
Q
What cellular process occurs most frequently in normal cells when compared to cells of tumour tissues?
A
Apoptosis
2
Q
Which protein is activated by the release of cytochrome c from mitochondria in the intrinsic pathway of apoptosis?
A
Apaf1
3
Q
What is regulated by association with the activating subunit Cdc20?
A
APC/C (Anaphase Promoting Complex)
4
Q
What contains a protease domain in its carboxy-terminal region and a small protein interaction domain near its amino terminus and is initially made in an inactive form?
A
Initiator caspase
5
Q
What is released from mitochondria and interacts with Appal-1 in the intrinsic pathway of apoptosis?
A
Cytochrome c
