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Laws, Regulations, and Policies > The Guide Ch2 > Flashcards

The Guide Ch2 Flashcards

1
Q
  1. The Guide Program of animal use and care includes which of the following animals?
    a. animals used in research
    b. animals used in testing
    c. animals used in training
    d. animals used in production
    e. all of the above
    f. all except d
A

e

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2
Q
  1. Animal care and use programs includes all EXCEPT:
    a. animal care
    b. veterinary care
    c. policies and procedures
    d. personnel and program management
    e. oversight
    f. Institutional Review Board (IRB)
    g. occupational health and safety
    h. animal facility design and management
    i. IACUC
A

f

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3
Q
  1. Which of the following regulatory requirements does the Guide take into consideration?
    a. Animal Welfare Regulations (USDA 1985)
    b. the Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS 2002)
    c. the U.S. Government Principles for Utilization and Care of Vertebrate Animals used in Testing, Research, and Training (IRAC 1985)
    d. b and c only
    e. a,b,c
A

e

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4
Q
  1. The U.S. Government Principles for Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training endorses all of the following principles EXCEPT:
    a. consideration of alternatives (in vitro systems, computer simula¬tions, and/or mathematical models) to reduce or replace the use of animals
    b. design and performance of procedures on the basis of relevance to human or animal health, advancement of knowledge, or the good of society
    c. use of appropriate species, quality, and number of animals
    d. avoidance or minimization of discomfort, distress, and pain
    e. use of appropriate sedation, analgesia, and anesthesia
    f. establishment of humane endpoints
    g. occupational health and safety by qualified person
    h. provision of adequate veterinary care
    i. provision of appropriate animal transportation and husbandry directed and performed by qualified persons
    j. conduct of experimentation on living animals exclusively by and/or under the close supervision of qualified and experienced personnel
A

g

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5
Q
  1. The primary oversight responsibilities in the Program rest with all EXCEPT:
    a. institutional official IO
    b. IACUC
    c. research investigators
    d. veterinarian
A

c

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6
Q
  1. Who bears the ultimate responsibility for the Pro¬gram?
    a. IO
    b. IACUC
    c. veterinarian
    d. research investigators
A

a

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7
Q
  1. Which of the following is not the responsibility of the IO?
    a. representative of senior administration
    b. bears ultimate responsibility for the Pro¬gram
    c. responsible for resource planning
    d. ensuring alignment of Program goals with institution’s mission
    e. must be a voting member of the IACUC
A

e

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8
Q
  1. Which of the following statement is INCORRECT regarding veterinarian responsibilities?
    a. responsible for the health and well-being of all laboratory animals used at the institution
    b. the AV is not responsible for overseeing animal husbandry and housing
    c. the AV is responsible for overseeing animal husbandry and housing
    d. clear and regular communication with the IACUC
A

b

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9
Q
  1. How often part time or consultative veterinarians need to visit animal facility?
    a. weekly
    b. monthly
    c. semi-annually
    d. intervals appropriate for programmatic needs
A

d

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10
Q
  1. The Guide endorses “Guidelines for Adequate Veterinary care” prepared by which organization?
    a. ECLAM 2001
    b. ACLAM 1996
    c. AALAS, 1994
    d. ASLAP 2003
A

b

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11
Q
  1. Guidelines for Adequate Veterinary care includes all EXCEPT
    a. access to all animals and their medical records
    b. regular veterinary visits to facilities where animals are or may be housed or used
    c. provisions for appropriate and competent clinical, preven¬tive, and emergency veterinary care
    d. regular veterinary visits to facilities only if animals are housed or used
    e. a system for legal animal procure¬ment and transportation.
A

d

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12
Q
  1. Which of the following statements regarding Interinstitutional collaboration is INCORRECT?
    a. should have a formal written understanding (e.g., a contract, memorandum of understanding, or agreement)
    b. the contract should addresses the responsibility for offsite animal care and use
    c. collaboration is mainly involve animal transport
    d. animal ownership
    e. IACUC review and oversight
    f. IACUCs from the participating institutions may choose to review protocols for the work being conducted
A

c

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13
Q
  1. True or False: All personnel involved with the care and use of animals should be adequately educated, trained, and/or qualified in basic principles of laboratory animal science to help ensure high quality science and animal well-being.
A

True

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14
Q
  1. True or False: The institution must provide the AV with sufficient authority, to include access to all animals, and resources to manage the program of veterinary care.
A

True

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15
Q
  1. True or False: If a full-time veterinarian is not available on site, visits by a consulting or part-time veterinarian should be at intervals appropriate to programmatic needs. In such instances, there must be an individual with assigned responsibility for daily animal care and use and facility management.
A

True

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16
Q
  1. The number and qualifications of personnel required to conduct and sup¬port a Program depend on which factors EXCEPT?
    a. the type and size of the institution
    b. the administrative structure for providing adequate animal care,
    c. the characteristics of the physical plant
    d. the financial status of the institution
    e. the number and species of animals maintained
    f. the nature of the research, testing, teaching, and production activities
A

d

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17
Q
  1. True or False: Institutions are responsible for providing appropriate resources to support personnel training.
A

True

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18
Q
  1. True or False: All Program personnel training should be documented.
A

True

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19
Q
  1. Who is responsible for providing oversight and for evaluating the effectiveness of the training program?
    a. IO
    b. IACUC
    c. Research investigator
    d. PAM (post-approval monitoring) personnel
A

b

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20
Q
  1. True or False: Veterinarians providing clinical and/or Program oversight and support should have the experience, training, and expertise necessary to appropriately evaluate the health and well-being of the species used, in the context of the animal use being carried out by the institution.
A

True

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21
Q
  1. True or False: Veterinarians providing broad Program direction should be trained or have relevant experience in laboratory animal facility administration and management
A

True

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22
Q
  1. True or False: The institution must provide opportunities and support for regular profes¬sional development and continuing education to ensure both that profes-sional staff are knowledgeable about the latest practices and procedures and that laboratory animals receive high-quality care
A

True

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23
Q
  1. True or False: The institution should provide for formal and/or on-the-job training for animal care personnel to facilitate effective implementation of the Program and the humane care and use of animals
A

True

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24
Q
  1. True or False: Personnel caring for laboratory animals should also regularly engage in continuing education activities and should be encouraged to participate in local and national laboratory animal science meetings and in other relevant professional organizations
A

True

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25
Q
  1. The Guide encourages coordinators of institutional training programs seek assistance from which of the following organizations?
    a. the Animal Welfare Information Center (AWIC)
    b. the Laboratory Animal Welfare and Training Exchange (LAWTE)
    c. AALAS,
    d. ILAR (NRC 1991).
    e. The Guide to the Care and Use of Experimental Animals by the Canadian Council on Animal Care (CCAC)
    f. all of the above
    g. all except “e”
A

f

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26
Q
  1. The Guide uses must for training of which of the following groups?
    a. veterinarians
    b. animal care personnel
    c. research team
    d. a only
    e. a and b only
    f. all of the above
A

d

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27
Q
  1. The research groups should receive training in all of the following areas, EXCEPT:
    a. in animal care and use legislation
    b. IACUC function
    c. ethics of animal use and the concepts of the Three Rs
    d. methods for reporting concerns about animal use
    e. occupational health and safety issues pertaining to animal use
    f. animal handling
    g. Animal transportation
    h. aseptic surgical technique
    i. anesthesia and analgesia
    j. euthanasia
A

g

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28
Q
  1. True or False: Continuing education programs should be offered to reinforce training and provide updates that reflect changes in technology, legislation, and other relevant areas.
A

True

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29
Q
  1. The frequency of the research team continuing education is
    a. every 2 years
    b. annually
    c. the Guide is silent
    d. every 4 years
A

c

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30
Q
  1. True or False: It is the institution’s responsibility to ensure that IACUC members are provided with training opportunities to understand their work and role.
A

True

31
Q
  1. The training areas for the IACUC members include all, EXCEPT:
    a. formal orientation to introduce new members to the institution’s Program
    b. relevant legislation, regulations, guidelines, and policies
    c. animal facilities and laboratories where animal use occurs
    d. the processes of animal protocol and program review
    e. formal training in animal disease prevention
    f. IACUC members may meet with animal care personnel and research teams
    g. be provided access to relevant journals, materials, and web-based training
    h. be given opportunities to attend meetings or workshops.
A

e

32
Q
  1. True or False: Each institution should establish and maintain an occupational health and safety program (OHSP) as an essential part of the overall Program of animal care and use. The OHSP should be consistent with federal, state, and local regulations and should focus on maintaining a safe and healthy workplace.
A

True

33
Q
  1. The requirement for occupational health and safety program (OHSP) is according to all of the following legislations EXCEPT:
    a. CFR 1984, a,b,c
    b. DHHS 2009
    c. Animal Welfare Regulations (USDA 1985)
    d. PHS 2002
A

c

34
Q
  1. An effective OHSP requires coordination between which of the following groups
    a. the research program (as represented by the investigator)
    b. the animal care and use Program (as represented by the AV, IO, and IACUC)
    c. the environmental health and safety program
    d. occupational health services
    e. administration (e.g., human resources, finance, and facility maintenance personnel)
    f. all of the above
A

f

35
Q
  1. T/F. Operational and day-to-day responsibility for safety in the workplace resides with the labora¬tory or facility supervisor (e.g. principal investigator, facility director, a staff veterinarian) and depends on safe work practices by all employees.
A

True

36
Q
  1. Managing hazard risks involve which of the following steps?
    a. the appropriate design and operation of facilities and use of appropriate
    b. safety equipment (engineering controls)
    c. the development of processes and standard operating procedures
    d. the provision of appropriate personal protective equipment (PPE) for employees
    e. all of the above
A

e

37
Q
  1. Which of the following is considered an engineering control?
    a. SOPs
    b. using respirators
    c. biological safety hoods
    d. safety practices
A

c

38
Q
  1. The extent and level of participation of personnel in the OHSP should be based on which of the followings?
    a. severity or seriousness of the hazard
    b. the exposure intensity
    c. duration, and frequency (prevalence of the hazard)
    d. the susceptibility (e.g., immune status) of the personnel
    e. the history of occupational illness and injury in the particular workplace
    f. all of the above
    g. all except e
A

f

39
Q
  1. Ongoing identification and evaluation of hazards call for:
    a. monthly inspection
    b. semi-annual inspection
    c. periodic inspection
    d. The Guide is silent
A

c

40
Q
  1. True or False: Because a high standard of personal cleanliness is essential, changing, washing, and showering facilities and supplies appropriate to the Program should be available.
A

True

41
Q
  1. T/F. Where biologic agents are used, the following standards should be consulted: the Centers for Disease Control and Prevention (CDC) and National Institutes of Health (NIH) publication bio¬safety in Microbiological and Biomedical Laboratories (BMBL; DHHS 2009), and USDA standards (USDA 2002).
A

True

42
Q
  1. Personnel safety training includes which of the following?
    a. zoonoses
    b. chemical, biologic, and physical hazards (e.g., radiation and allergies)
    c. unusual conditions or agents that might be part of experimental procedures (e.g., the use of human tissue in immunocompromised animals)
    d. handling of waste materials
    e. personal hygiene
    f. the appropriate use of PPE
    g. health considerations (e.g., pre¬cautions to be taken during pregnancy, illness, or immunosuppression)
    h. all of the above
A

h

43
Q
  1. True or False: Outer garments worn in the animal rooms should not be worn outside the animal facility unless covered.
A

True

44
Q
  1. True or False: Soiled attire should be disposed of, laundered, or decontaminated by animal care and use personnel.
A

False - by the institution, using an outside vendor as appropriate

45
Q
  1. The Guide states personnel working with animals restricts the activity of all EXCEPT:
    a. eat, drink, use tobacco products
    b. use cell phones
    c. apply cosmetics
    d. handle or apply contact lenses
A

b

46
Q
  1. The procedures that require specific safe¬guards for animal experimentation with hazardous agent include, which of the following
    a. animal care and housing
    b. storage and distribution of the agents
    c. dose preparation and administration
    d. body fluid and tissue handling, waste and carcass disposal
    e. items that might be used temporarily and removed from the site (e.g., written records, experimental devices, sample vials)
    f. personal protection.
    g. all except, e
    h. all of the above
A

h

47
Q
  1. What is the responsibility of institutions for animal experimentation with hazardous biologic, chemical, and physical agents?
    a. should have written policies and procedures governing experimentation
    b. an oversight process
    c. formal safety programs should be established to assess hazards, determine the safeguards needed for their control
    d. ensure that staff has the necessary training and skills and those facilities are adequate for the safe conduct of the research.
    e. technical support should be provided to monitor and ensure compliance with institutional safety policies
    f. all of the above
A

f

48
Q

T/F. Facilities that handle agents of unknown risk should consult with appropriate USDA personnel about hazard control and medical surveillance.

A

False - CDC personnel, not USDA

49
Q
  1. The use of which of the followings associated with HIGHEST risk of human infection?
    a. immunodeficient mice
    b. genetically modified animals (GMAs) susceptible to or shedding human pathogens
    c. imunocompetent mice
    d. a and b only
    e. All of the above
A

b

50
Q
  1. Which of the following two controls are the first considerations for the protection of personnel?
    a. engineering and administrative controls
    b. engineering and PPE controls
    c. PPE and administrative controls
A

a

51
Q
  1. Which of the followings are true about PPE?
    a. appropriate, personnel should shower when they leave the animal care, procedure, or dose preparation areas
    b. institution-issued protective clothing
    c. Protective clothing and equipment should not be worn beyond the boundary of the hazardous agent work area or the animal facility
    d. All of the above
    e. All except b
A

d

52
Q
  1. Which of the following PPE is needed for personnel exposed to nonhuman primates?
    a. Gloves
    b. arm protectors
    c. suitable face masks
    d. face shields
    e. goggles
    f. all of the above
A

f

53
Q
  1. Personnel working in areas where they might be exposed to contaminated airborne particulate materials or vapors should have all EXCEPT:
    a. respiratory protection
    b. respirator fit testing and training
    c. proper use and maintenance of the respirator
    d. surgical mask
A

d

54
Q
  1. Which the following does the Guide indicate as ADVISIBLE (not should or must) for preventive medicine of personnel?
    a. A pre-employment health evaluation and/or a health history evaluation before work assignment
    b. Periodic medical evaluations for personnel in specific risk categories
    c. An appropriate immunization schedule.
    d. A and b
    e. A and c
    f. A,b and c
A

d

55
Q
  1. Which of the following is INCORRECT regarding preventive medicine for personnel?
    a. It is important to immunize animal care personnel against tetanus
    b. pre-exposure immunization should be offered to people at risk of infection or exposure to specific agents such as rabies virus (e.g., if working with species at risk for infection) or hepatitis B virus (e.g., if work¬ing with human blood or human tissues, cell lines, or stocks).
    c. Vaccination is recommended if research is to be conducted on infectious diseases for which effective vaccines are available.
    d. Pre-employment or pre-exposure serum collection for all employees working with pathogenic agents
A

d - preexposure serum only in specific circumstances

56
Q

What should the medical surveillance program include?

A

1) Promote early diagnosis of allergies
2) Include evaluation of preexisting allergies
3) Personnel training should include information about animal allergies, preventative control measures, early recognition and reporting of allergy symptoms, and proper techniques for working with animals.

57
Q

How should PPE be used in relation to engineering and process controls?

A

PPE should supplement, not replace

58
Q

The institution (is advised, must, or should) develop methods for reporting and investigating animal welfare concerns and employees should be aware of the importance of and mechanisms for reporting animal wel¬fare concern.

A

MUST

59
Q

In the United States, responsibility for review and investi¬gation of animal welfare concerns rests with:

a. the IO and the IACUC
b. IO and Veterinarian
c. IACUC and Veterinarian
d. CEO and IO

A

a

60
Q

According to the Guide IACUC membership include all, EXCEPT:

a. doctor of Veterinary Medicine
b. an IACUC chair
c. at least one practicing scientist experienced in research involving animals
d. at least one member from a nonscientific background, drawn from inside or outside the institution
e. at least one public member to represent general community inter¬ests in the proper care and use of animals.

A

b

61
Q

Which of the following is INCORRECT about the public member?

a. Public members should not be laboratory animal users, affiliated in any way with the institution.
b. Public members should not be members of the immediate family of a per-son who is affiliated with the institution.
c. The public member should not receive any compensation for participation and ancillary expenses
d. All are correct

A

c

62
Q

The Guide state for large institutions with many administrative units or departments, no more than how many voting members should be associated with a single administrative unit.

a. 2
b. 3
c. 4
d. 1

A

b

63
Q

The first off¬spring of a newly generated GMA line should be carefully observed for signs of disease, pain, or distress from:

a. birth into early adulthood
b. during early age
c. during old age
d. birth to weaning

A

a

64
Q

True or False: When the initial characterization of a GMA reveals a condition that negatively affects animal well-being, this should be reported to the IACUC

A

True

65
Q

The guidelines for restraining includes all EXCEPT:

a. restraint devices should not be considered a normal method of housing, and must be justified in the animal use protocol.
b. restraint devices can be used simply as a convenience in handling or managing animals
c. alternatives to physical restraint should be considered.
d. the period of restraint should be the minimum required to accom¬plish the research objectives.
e. animals to be placed in restraint devices should be given train¬ing (with positive reinforcement) to adapt to the equipment and personnel.
f. animals that fail to adapt should be removed from the study.
g. provision should be made for observation of the animal at appropri¬ate intervals
h. veterinary care must be provided if lesions or illnesses associated with restraint are observed. The presence of lesions, illness, or severe behavioral change often necessitates the temporary or per¬manent removal of the animal from restraint.
i. the purpose of the restraint and its duration should be clearly explained to personnel involved with the study.

A

b

66
Q

Multiple major surgical procedures on a single animal are acceptable only if they are:

A

1) included in and essential components of a single research protocol
2) scientifically justified by the investigator, or
3) necessary for clinical reasons

67
Q

T/F. Conservation of scarce animal resources may justify the conduct of multiple major surgeries on a single animal.

A

True - but the application of such practice on a single animal used in separate protocols is discouraged and should be reviewed critically by the IACUC

68
Q

True or False: Some procedures characterized as minor may induce substantial post-procedural pain or impairment and should similarly be scientifically justified if performed more than once in a single animal

A

True

69
Q

Who must submit a request to the USDA/APHIS and receive approval in order to allow a regulated animal to undergo multiple major survival surgical procedures in separate unrelated research protocols

a. PI
b. IO
c. IACUC
d. AV

A

b

70
Q

The development of animal protocols that involve the use of food or fluid regulation requires the evaluation of what three factors.

A

1) the necessary level of regulation
2) potential adverse consequences of regulation
3) methods for assessing the health and well-being of the animals

71
Q

How often should body weights be recorded for animals undergoing food or fluid regulation?

A

At least weekly and more often for animals requiring greater restrictions

72
Q

Describe written record requirements for animals undergoing food or fluid regulation.

A

Written records should be maintained for each animal to document daily food and fluid consumption, hydration status, and any behavioral and clinical changes used as criteria for temporary or permanent removal of an animal from a protocol.

73
Q

True or False: In the case of conditioned-response research protocols, use of a highly preferred food or fluid as positive reinforcement, instead of restriction, is recommended

A

True

74
Q

Both the _______ and _________ require the IACUC to inspect animal care and use facilitates every _________

A

HREA, AWA, 6 months

Laws, Regulations, and Policies (26 decks)

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