The Guide Ch1

Question 1

True or False: Replacement refers to methods that avoid using animals
in research.

Answer 1

True

Question 2

Replacement may be achieved by

a. Using inanimate study systems such as computer models
b. Using animals that are lower on the phylogenetic tree
c. Both a and b

Answer 2

c

Question 3

Modification of animal husbandry to experimental procedure to
minimize pain/stress/suffering is known as
a. replacement
b. reduction
c. refinement

Answer 3

c

Question 4

True or False: The Guide establishes the minimal care, ethical and
practice standards for the use of vertebrate animals in biomedical
research.

Answer 4

True

Question 5

Obtaining comparable information from fewer animals or maximizing information obtained from a given number of animals without increasing pain or distress may be achieved by:

a. Using newer technologies
b. Analysis of experimental design
c. Use of appropriate statistical method
d. Control of environmentally related variability in animal housing and study areas
e. All of the above

Answer 5

e. All of the above

Question 6

The animal care and use program includes:

a. Establishment and support of an IACUUC
b. Facilities in which animals will be housed and studied
c. Policies, procedures, standards and practices established to ensure humane animal care
d. Staffing
e. Organizational structure
f. All of the above

Answer 6

f. All of the above

Question 7

In the United States of America, the use of animals for research is governed by:

a. The Animal welfare act
b. PHS policy
c. The GUIDE
d. All of the above

Answer 7

d. All of the above

Question 8

The Guide covers:

a. traditional laboratory animals
b. agricultural animals
c. wildlife
d. aquatic species
e. all of the above

Answer 8

e. all of the above –> ANY VERTEBRATE ANIMAL

Question 9

True or False: The guide governs animals produced for and used in
research, testing, teaching.

Answer 9

True

Question 10

True or False: Replacement refers to methods that avoid using animals in research.

Answer 10

True

Question 11

Replacement may be achieved by which of the following?

a. Using inanimate study systems such as computer models
b. Using animals that are lower on the phylogenetic tree

Answer 11

both are correct

Question 12

True or False: The Guide is written in general terms so that its recommendations may be applied in diverse institutions and settings.

Answer 12

True

Question 13

True or False: Professional judgment must be used in implementing the recommendations of the guide.

Answer 13

True

Question 14

True or False: The IACUC plays a central role in interpretation, implementation, oversight and evaluation of the institutional animal
care and use program.

Answer 14

True

Question 15

Who published the Three R’s and in what year?

Answer 15

W.M.S Russell and R.L. Burch in 1959

Question 16

Practical statements of collective wisdom, convention, or management direction that are internal to the entity are:

a. policy
b. principles
c. procedures

Answer 16

a. policy

Question 17

Accepted generalizations about a topic that are frequently endorsed by many and diverse organizations are:

a. policy
b. principles
c. procedures

Answer 17

b. principles

Question 18

True or False: Establishing standard operating procedures can assist and institution in complying with regulations, policies and principles as well as with day-to-day operations and management.

Answer 18

True

Question 19

True or False: In most situations, the Guide is intended to provide flexibility so that institutions can modify practices and procedures with changing conditions and new information.

Answer 19

True

Question 20

A standard or guideline that specifies in detail a method, technology or technique for achieving a desired outcome is a ______ standard

a. engineering
b. practice
c. performance

Answer 20

a. engineering - they are prescriptive and provide limited flexibility for implementation

Question 21

A standard or guideline that provides for flexibility in achieving a desired outcome by allowing professional judgment is a ___ standard

a. engineering
b. practice
c. performance

Answer 21

c. performance

Question 22

An approach that has been demonstrated, over time, to be beneficial to complete a task or process through the exercise of professional judgment by qualified experienced individuals is a ____standard.

a. engineering
b. practice
c. performance

Answer 22

b. practice

Question 23

Detailed step-by-step processes meant to insure the consistent application of institutional practices are

a. policy
b. principles
c. procedures

Answer 23

c. procedures