BB LRGPHOR _Ch1 - Regs

Question 1

4. The 3Rs are emphasized in training programs for scientists and IACUCs. The term Refinement refers to what?
   a. Strategies for obtaining comparable levels of information from the use of fewer animals
   b. Modification of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress
   c. Methods that avoid using animals
   d. All of the above

Answer 1

b

Question 2

7. The principal of non-maleficence is based upon what idea?

Answer 2

That minimization of distress, pain, and suffering is a moral imperative

Question 3

11. If an IACUC is composed of more than three members, what is the maximum number of members that may be appointed from the same administrative unit?

Answer 3

3

Question 4

15. Which statement is true?
    a. The Public Health Service (PHS) Policy requires an IACUC to have a minimum of five members with at least one member being a practicing scientist with experience in animal research.
    b. The Public Health Service (PHS) Policy requires an IACUC to have a minimum of three members with at least one member being a practicing scientist with experience in animal research.
    c. The AWA requires an IACUC to have a minimum of five members with at least one member being a practicing scientist with experience in animal research.
    d. The AWA requires an IACUC to have a minimum of three members with at least one member being a practicing scientist with experience in animal research.

Answer 4

a

Question 5

17. A “Memorandum of Understanding concerning Laboratory Animal Welfare,” intended to maintain and enhance agency effectiveness while avoiding duplication of efforts, was signed by all except which one of the following agencies?
    a. Food and Drug Administration (FDA)
    b. National Institutes of Health (NIH)
    c. United States Department of Agriculture (USDA)
    d. Drug Enforcement Administration (DEA)

Answer 5

d

Question 6

18. The Environmental Protection Agency (EPA) has established Good Laboratory Practices (GLPs) for conduct of studies using animals which are required to register new:
    a. pesticide products.
    b. industrial chemicals.
    c. food additives.
    d. vaccines.

Answer 6

a

Question 7

39. The 3Rs are emphasized in training programs for scientists and IACUCs. The term Replacement refers to what?
    a. Strategies for obtaining comparable levels of information from the use of fewer animals
    b. Modification of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress
    c. Methods that avoid using animals
    d. All of the above

Answer 7

c

Question 8

40. Indicators of pain in rodents would not include which of the following?
    a. Rapid, shallow respiration and abnormal stance or arched back
    b. Failure to nest and decreased food/water consumption
    c. Head pressing and teeth grinding
    d. Self-mutilation and piloerection

Answer 8

c

Question 9

41. Indicators of pain in rabbits would not include which of the following?
    a. Rapid, shallow respiration and hunched posture
    b. Excessive salivation and decreased food/water consumption
    c. Head pressing and teeth grinding
    d. Self-mutilation and tremors

Answer 9

d

Question 10

47. True or False: The AWA requires that an IACUC has a scientist as at least one of the three members.

Answer 10

False

Question 11

50. True or False: The Toxic Substances Control Act (TSCA) has GLP standards for conducting required industrial chemical studies.

Answer 11

True