The Eye Flashcards
Dark current channels close and less Ca is entering. Ca inhibits the synthesis of cGMP by guanylyl cyclase and thus with less unerring guanylyl cyclase is more active and cGMP synthesis inc. Dark channel currents gradually open and depolarize cones so that they have a range through white they can function in the light
Light adaptation
Neural tissue at the back of the eye
Retina
Carry red-green and blue-yellow info
P and nonm-nonp ganglion cells
Respond to the opposite way the photoreceptors communicating with them do. Metabotropic glutamate receptors (light is preferred stimulus)
On type (sign inverting) bipolar cells
Fewer disks, contain red, blue, or green pigments
Cones
Only output cells, fire APs
Ganglion cells
The cornea uses this since there is air in front and fluid behind (aqueous humor)
Refraction
Bending of light when traveling from one medium to another
Refraction
What does it mean when we say our visual system doesn’t detect differences in absolute values?
Not great in uniformly light/dark environments
SLIDE 45
SLIDE 45
More sensitive to light bc rods more sensitive to low light, more photoreceptors per ganglion cell
Peripheral retina
What does the G protein (transducin) do when rhodopsin is hit by light?
Activates phosphodiesterase and reduces the level of cGMP
All the complex data we need to construct our perception of the world is gathered by this
Retina
How does light activate rhodopsin?
Light strikes retinal and changes its shape to linear and the color of rhodopsin changes
Distance between peaks
Wavelength
Are red on center, green off surround or green on center, red off surround. Red and green are opponent colors
P type cells
Release GABA as a NT
Horizontal cells
Transfer of light energy, compounds do this with light of specific wavelengths and reflect others
Absorption
Used in daylight (photopic) to detect color. Many more photons are required to activate these photoreceptors. Not very active in the dark
Cones
SLIDE 59
SLIDE 59
What happens when Na and Ca stop flowing into rhodopsin?
The cell is hyper polarized (more negative)
These photoreceptors and 1000x more sensitive to the others and are thus used for night vision (scotopic) and shut down in bright light
Rods
90% of the ganglion cells. Contact one to a few cone bipolar. They have, small concentric receptive fields, produce sustained slowly adapting responses, with a weak response to movement. Good at analyzing SHAPES
P type
Respond to light at 560 nm (l)
Red cones
Scotopic vs photopic vision
S - night vision. rods
P - day vision. cones
Light being bounced off of a surface
Reflection
SLIDE 35
SLIDE 35
Theory that brain assigns colors based on comparison fo cone readouts, more to it than this though including the color opponent process
Young-Helmholtz trichromacy theory
Light sensitive part of retina
Layer of photoreceptor outer segments
Xanthophylls here protect eye from near UV light and act as antioxidants
Macula
Ganglion cells that sustain APs for longer
P type
Overall cell response is to send information about light vs dark, red vs gree, blue vs yellow, movement, detail (like shapes)
Ganglion cells
There is usually poor contrast sensitivity at first, results from cones being hyper polarized at first due to dark current channels closing
Light adaptation
Response in center to one wavelength is cancelled by other wavelength (opponent only) in surround. This is similar to the center surround organization seen for light or dark except that specific cones are present in only the center or the surround
Color opponent cells
Respond to the same way the photoreceptors communicating with them do. Inotropic glutamate receptors (dark is preferred stimulus)
Off type (sign conserving) bipolar cells
Where the optic nerve exits the eye, blood vessels but no photoreceptors (blind spot)
Optic disc
SLIDE 46 and 47 and 48!!!
SLIDE 46 and 47 and 48!!!
This does most of the light bending for the eye
Cornea
What does light act as for a GPCR
Agonist
At back fo retina to absorb stray light, remove old discs, regenerate photopigment
Pigment epithelium
Peak minus trough
Amplitude
Respond to light at 530 nm (m)
green cones
The only light sensitive cells
Photoreceptors
The lens does this when looking at a distance and this when looking close up
Distance - flattens
Close up - more rounded
What range of intensity do photoreceptors work at? What does this mean?
100 fold range in intensity. At 1/10 of ambient light are maximally depolarized and at 10x ambient light are maximally hyperpolarized
Photoreceptors stop working and blindness in certain areas can result
Detached retina
Ganglion cells have these while photoreceptors do not. They function as an area of the visual field that feeds information a particular ganglion cells
Receptive fields
Information gathered in the retina is ultimately sent here
Primary visual cortex
5% of ganglion cells with some being color sensitive. Good with COLOR
non-m non-p type
Beyond on and off center, how are ganglion cells categorized?
P (midget) type
M (parasol) type
Non-M non-P
Said all colors created by mixing red, green, and blue light and the retina senses this. This was only a prediction at his time
Young
These photoreceptors communicate directly with bipolar cells
Center photoreceptors
Has more receptor cells per ganglion cell and more rods than cones
Peripheral retina
Transparent with no blood vessels
Cornea
Tough wall of the eyeball
Sclera
With small fields, carry info regarding fine detail
P type ganglion cells
Light is slowed by this in front of the cornea
Aqueous humor
Many disks and large amount of rhodopsin
Rods
Don’t fire APs. Respond by releasing more NT if depolarized and less NT if hyperpolarized
Bipolar cells
What are the two functions of the eye?
- camera like system to focus light on the retina
2. neural retina; generate a pattern of APs from the input of many photons striking photoreceptors
Failure of lens accommodation. Impairs close up vision needed for reading
Presbyopia
SLIDES 40 AND 41
SLIDES 40 AND 41
This is a type of electromagnetic radiation that exists on the EM spectrum that we see
Light
Involves both eyes (consensual) pupil of one does the same as the other (both dilate or constrict in light)
Pupillary light reflex
Can be thought of as all the bipolar cells communicating with them and they have receptive fields as well
Ganglion cells
Bipolar, amacrine, ganglion synaptic contacts of retina
Inner plexiform layer
Light hits behind retina, cant see close up (farsightedness)
Hyperopia
What type of receptor is rhodopsin?
GPCR (7 TM regions coupled with G protein inside cell)
Ability to distinguish between nearby points (20/20 = 0.83 degrees). Due to refractive power and spacing of photoreceptors
Visual acuity