The B lymphocyte Response Flashcards
B-lymphocytes and the ……………..
humoral immune response
B-lymphocytes (B cells) remain in the bone marrow until they are mature and then
spread through the body, concentrating in lymph nodes and the spleen
Millions of types of B-lymphocyte cells are produced within us because as they mature the
genes coding for antibodies are changed to code for different antibodies
Once mature, each type of B-lymphocyte cell can make
one type of antibody molecule
Once mature, each type of B-lymphocyte cell can make one type of antibody molecule
At this stage, the antibody molecules do not leave the B-lymphocyte cell but remain in the …………
cell surface membrane
Part of each antibody molecule forms a
glycoprotein receptor that can combine specifically with one type of antigen
Part of each antibody molecule forms a glycoprotein receptor that can combine specifically with one type of antigen
If that antigen enters the body, B-lymphocyte cells with the correct cell surface receptors will be able to
recognise it and bind to it (clonal selection
These specific B-lymphocytes divide repeatedly by mitosis (clonal expansion) and differentiate into two main types of cell:
Plasma cells
Memory cells