replication of hiv Flashcards
step 1 When the virus enters the bloodstream it infects a certain type of lymphocyte -
helper T cells
Normally lymphocytes seek out and destroy pathogens that enter the body, producing antibodies that attach to pathogens and enhancing phagocytic activity
HIV avoids being recognised and destroyed by lymphocytes by
repeatedly changing its protein coat
second stage
The virus uses the cell machinery of helper T-cells to multiply how
Viral RNA enters the cell
Viral reverse transcriptase enzymes produce a DNA copy of the viral RNA
The DNA copy is inserted into the chromosomes of the cell
Each time the cell divides it copies the viral DNA
The infected cells remain normal as the viral DNA is inactive
third stage
At this stage, the individual is HIV positive and will have antibodies against the virus
After a period of time (possibly years) the viral DNA within the host cells becomes active and
It takes control of the helper T cell
More HIV particles are produced
This causes the helper T cell to die
As a result, thousands of new HIV particles are released which are able to infect other helper T cells
forth stage Gradually the virus reduces the number of helper T cells in the immune system
till
B cells are no longer activated
No antibodies are produced
This decreases the body’s ability to fight off infections, eventually
leading to AIDS (Acquired immune deficiency syndrome)