Primary immune response Flashcards
When an antigen enters the body for the first time, the small numbers of B-lymphocytes with receptors complementary to that antigen are stimulated to divide by mitosis
This is known as
clonal selection
As these clones divide repeatedly by mitosis (the clonal expansion stage) the result is large numbers of
identical B-lymphocytes being produced over a few weeks
Some of these B-lymphocytes become plasma cells that secrete lots of
antibody molecules (specific to the antigen) into the blood, lymph or linings of the lungs and the gut
These plasma cells are short-lived (their numbers drop off after several weeks) but the antibodies they produce
the antibodies they have secreted stay in the blood for a longer time
The other B-lymphocytes become memory cells that remain circulating in the blood for a long time
This response to a newly encountered pathogen is relatively
slow