Tetracyclines DI Flashcards
1
Q
Tetracyclines
A
Tetracycline, doxycycline
2
Q
Tetracyclines MoA
A
Reversibly bind to the 30S ribosomal subunit and inhibit bacterial protein synthesis
3
Q
Are TTCs bacteriostatic or bactericidal?
A
Bacteriostatic
4
Q
TTCs spectrum of activity
A
+++ against gram-positive aerobes
+ against gram-negative aerobes
5
Q
TTCs side effects
A
GI intolerance, phototoxicity, Fanconi syndrome
6
Q
PO absorption is decreased by administration of what?
A
Di- and trivalent cations (milk, antacids, sucralfate, didanosine)
