Lipopeptide DI Flashcards
1
Q
Lipopeptide
A
Daptomycin
2
Q
Lipopeptide MoA
A
Irreversibly binds to the bacterial cell membrane, rapidly depolarizes it, and causes cell death
3
Q
Are lipopeptides bacteriostatic or bactericidal?
A
Bactericidal
4
Q
Daptomycin spectrum of activity
A
+++ against gram-positive anaerobes, MRSA, MSSA, and enterococcus
+/++ activity against gram-negative anaerobes
No activity against gram-negative aerobes
5
Q
Daptomycin isn’t indicated for what?
A
Pneumonia
6
Q
Daptomycin monitoring
A
Muscle pain or weakness, CPK levels