Fluoroquinolones DI

Question 1

Fluoroquinolones

Answer 1

Ciprofloxacin, levofloxacin, moxifloxacin

Question 2

Fluoroquinolones MoA

Answer 2

Inhibit DNA gyrase which results in breakage of bacterial DNA

Question 3

Are fluoroquinolones bacteriostatic or bactericidal?

Answer 3

Bactericidal

Question 4

Ciprofloxacin spectrum of activity

Answer 4

+/++ against gram-positive aerobes
+ against enterococcus
++ against MSSA
+++ against gram-negative aerobes, atypical, and pseudomonas

Question 5

Levofloxacin spectrum of activity

Answer 5

+++ against gram-positive aerobes, MSSA, gram-negative aerobes, and atypicals
+/++ against enterococcus and pseudomonas

Question 6

Moxifloxacin spectrum of activity

Answer 6

+++ against gram-positive aerobes

Question 7

Fluoroquinolones side effects

Answer 7

GI intolerance, headache, seizures, dizziness, QTc prolongation

Question 8

Fluoroquinolones are preferred for…

Answer 8

…pseudomonas and hospital-acquired organisms

Question 9

Fluoroquinolones aren’t recommended for what groups of people?

Answer 9

Children <18 years and pregnant women