Aminoglycosides DI

Question 1

Aminoglycosides

Answer 1

Gentamicin, tobramycin, amikacin

Question 2

Aminoglycosides MoA

Answer 2

Bind to the 30S ribosomal subunit and inhibit bacterial protein synthesis

Question 3

Are aminoglycosides bacteriostatic or bactericidal?

Answer 3

Bactericidal

Question 4

Gentamicin spectrum of activity

Answer 4

+++ against gram-positive and gram-negative aerobes

Question 5

Tobramycin and amikacin spectrum of activity

Answer 5

+++ against gram-negative aerobes

Question 6

Aminoglycosides side effects

Answer 6

Nephrotoxicity, ototoxicity, enhanced neuromuscular blockade

Question 7

The side effects of aminoglycosides are…

Answer 7

…dose-dependent

Question 8

Efficacy of aminoglycosides against gram-negative organisms

Answer 8

Amikacin&raquo_space; tobramycin&raquo_space;> gentamicin