Penicillins DI Flashcards
Natural penicillins
Pen G and Pen V
Aminopenicillin
Ampicillin
Penicillinase resistant penicillin
Nafcillin, dicloxacillin
Ureido-penicillin
Piperacillin
Beta-lactam/beta-lactamase inhibitor combination PCNs
Amox/clav, ampicillin/sulbactam, ticarcillin/clav, pip/tazo
PCN MoA
Bind to transpeptidase enzymes in the bacterial cell and disrupt cell wall formation
Are PCNs bacteriostatic or bactericidal?
Bactericidal
Pen G snd Pen V spectrum of activity
+++ against gram-positive organisms and enterococcus
Pen G and Pen V side effects
Hypersensitivity, rash, seizures, CDAD
Ampicillin spectrum of activity
+++ against gram-positive organisms and enterococcus
Ampicillin side effect
Mononucleosis rash
Nafcillin and dicloxacillin spectrum of activity
+++ against gram-positive aerobes and MSSA
Nafcillin and dicloxacillin side effects
Neutropenia, interstitial nephritis, thrombophlebitis
Piperacillin spectrum of activity
+++ against pseudomonas
Piperacillin side effects
Neutropenia, diarrhea, headache
Beta-lactam-beta-lactamase inhibitor combination spectrum of activity
+++ against gram-negative AEROBES
Beta-lactam-beta-lactamase inhibitor combination spectrum side effect
Diarrhea
PCNs may have cross-reactivity with what two other ABX classes?
Carbapenems and cephalosporins
