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PHM 603- ID Part 1 > PK/PD of Antimicrobials > Flashcards

PK/PD of Antimicrobials Flashcards

1
Q

Drugs that follow time-dependent killing and minimal/moderate persistent effects

A 
Penicillin
Cephalosporins
Carbapenems
Macrolides
Oxazolidiones
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2
Q

Dosing goals for drugs that follow time-dependent killing and minimal/moderate persistent effects

A

Prolonged infusion time
Continuous infusion
Shorter dosing interval
Increased dose

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3
Q

Key parameter for drugs that follow time-dependent killing and minimal/moderate persistent effects

A

%T > MIC

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4
Q

Drugs that follow concentration-dependent and prolonged persistent effects

A

Aminoglycosides

Quinolones

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5
Q

Dosing goal for drugs that follow concentration-dependent and prolonged persistent effects

A

Extended interval dosing, maximize safe dose

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6
Q

Key parameter for drugs that follow concentration-dependent and prolonged persistent effects

A

Cmax:MIC
AUC:MIC ratio

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7
Q

Drugs that follow time-dependent and prolonged persistent effects

A

Vanco
Azithromycin
Tetracycline

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8
Q

Dosing goal for drugs that follow time-dependent and prolonged persistent effects

A

Optimize safe dose

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9
Q

Key parameter for drugs that follow time-dependent and prolonged persistent effects

A

AUC:MIC ratio

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10
Q

ABX that DO NOT need renal dose adjustments

A 
Ceftriaxone
Clindamycin
Oxacillin
Metronidazole
Moxifloxacin
Azithromycin
Nafcillin
Doxycycline
Erythromycin
Daifopristin/quinupristin
Linezolid
Tigecycline
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11
Q

High CL and Vd means what?

A

Low concentration

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12
Q

Low CL and Vd means what?

A

High concentration

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13
Q

PK alteration when blood is the infection site

A

Expanded Vd and enhanced CL

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14
Q

PK alteration when the lung is the infection site

A

Impaired permeability

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15
Q

PK alteration when soft tissue is the infection site

A

Variable by composition

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16
Q

PK alteration when bone is the infection site

A

Impaired permeability

17
Q

PK alteration when the CNS is the infection site

A

Impaired permeability

18
Q

When a drug’s given MIC is lower than another drug’s, does it mean it works better?

A

No

19
Q

When the MIC of a drug is “a lot” lower vs. “a little” lower than the breakpoint, does that mean it will work any better/worse?

A

No

20
Q

PK/PD target for vanco

A

AUC:MIC >400

21
Q

AUC:MIC is dependent on what factors?

A

Daily dose a patient is getting
Patient-specific CL
Bacterial-specific MIC

22
Q

Best way to determine patient-specific CL

A

Bayesian

23
Q

Okay way to determine patient-specific CL

A

Analytical calculation of peaks and troughs

24
Q

Worst way to determine patient-specific CL

A

Trough levels

PHM 603- ID Part 1 (22 decks)

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