PK/PD of Antimicrobials Flashcards
Drugs that follow time-dependent killing and minimal/moderate persistent effects
Penicillin Cephalosporins Carbapenems Macrolides Oxazolidiones
Dosing goals for drugs that follow time-dependent killing and minimal/moderate persistent effects
Prolonged infusion time
Continuous infusion
Shorter dosing interval
Increased dose
Key parameter for drugs that follow time-dependent killing and minimal/moderate persistent effects
%T > MIC
Drugs that follow concentration-dependent and prolonged persistent effects
Aminoglycosides
Quinolones
Dosing goal for drugs that follow concentration-dependent and prolonged persistent effects
Extended interval dosing, maximize safe dose
Key parameter for drugs that follow concentration-dependent and prolonged persistent effects
Cmax:MIC
AUC:MIC ratio
Drugs that follow time-dependent and prolonged persistent effects
Vanco
Azithromycin
Tetracycline
Dosing goal for drugs that follow time-dependent and prolonged persistent effects
Optimize safe dose
Key parameter for drugs that follow time-dependent and prolonged persistent effects
AUC:MIC ratio
ABX that DO NOT need renal dose adjustments
Ceftriaxone Clindamycin Oxacillin Metronidazole Moxifloxacin Azithromycin Nafcillin Doxycycline Erythromycin Daifopristin/quinupristin Linezolid Tigecycline
High CL and Vd means what?
Low concentration
Low CL and Vd means what?
High concentration
PK alteration when blood is the infection site
Expanded Vd and enhanced CL
PK alteration when the lung is the infection site
Impaired permeability
PK alteration when soft tissue is the infection site
Variable by composition
PK alteration when bone is the infection site
Impaired permeability
PK alteration when the CNS is the infection site
Impaired permeability
When a drug’s given MIC is lower than another drug’s, does it mean it works better?
No
When the MIC of a drug is “a lot” lower vs. “a little” lower than the breakpoint, does that mean it will work any better/worse?
No
PK/PD target for vanco
AUC:MIC >400
AUC:MIC is dependent on what factors?
Daily dose a patient is getting
Patient-specific CL
Bacterial-specific MIC
Best way to determine patient-specific CL
Bayesian
Okay way to determine patient-specific CL
Analytical calculation of peaks and troughs
Worst way to determine patient-specific CL
Trough levels
