Tetracyclines

Question 1

What are the tetracyclines?

Answer 1

1. Doxycycline
2. Tetracycline
3. Minocycline: not on chart

Question 2

What are the routes of administration for the tetracycline?

Answer 2

1. Doxycycline: IV/PO
2. Tetracycline: PO
3. Minocycline: not on chart: PO

Question 3

What is the MOA for the tetracyclines?

Answer 3

1. Passive diffusion through the porins in gram negative organisms
2. Inhibits 30S ribosome: blocks access of tRNA anticodon to its codon, prevents protein synthesis

Question 4

What gram positive organisms are tetracyclines effective against?

Answer 4

1. Strep pneumonia

2. CA-MRSA

Question 5

What gram negative organisms are tetracyclines effective against?

Answer 5

1. H. influenzae
2. Neiserria
3. Rickettsia

Question 6

What spirpchetes are tetracyclines effective against?

Answer 6

1. Spirochetes: Borrelia burgdorferi

Question 7

What are the clinical uses for tetracyclines?

Answer 7

1. Uncomplicated respiratory infections
   A. Bronchitis, sinusitis, CAP
2. Drugso f choice for tick-borne illnesses
3. H. pylori cocktail

Question 8

What are the SE for tetracyclines?

Answer 8

1. GI: N/V/D
2. Photosensitivity
3. Discoloration of teeth in children, infants
4. Teratogenic?
5. Pill esophagitis: take with water and stand up

Question 9

What drug interactions are present with tetracyclines?

Answer 9

1. Chelate cations: separate by a few hours
A. Calcium
B. Iron
C. Antacids
D. MVI