Oxazolidinones

Question 1

What are the Oxazolidinones?

Answer 1

1. Linezoid (Zyvox): on chart

2. Tedizolid: NOT on chart

Question 2

What is the MOA for Linezoid (Zyvox)?

Answer 2

1. Protein synthesis inhibitor

2. binds to 23S ribosomal RNA of the 50S subunit inhibiting protein synthesis

Question 3

What gram positive bacteria is Linezoid (Zyvox) effective against?

Answer 3

1. S. aureus (MRSA, MSSA)
2. Enterococcus including VRE
3. Coagulase negative staph
4. Streptococci

Question 4

What gram negative bacteria is Linezoid (Zyvox) effective against?

Answer 4

NONE

Question 5

What anaerobic bacteria is Linezoid (Zyvox) effective against?

Answer 5

Clinical activity poor

Question 6

What are the clinical indications for Linezoid (Zyvox)?

Answer 6

1. Gram positive infections: usually as alternative therapy to vancomycin
2. VRE
3. Avoid for MRSA bacteremia, endocarditis

Question 7

What are the SE for linezoid (Zyvox)?

Answer 7

1. Allergies
2. Agranulocytosis
3. Reversible myelosuppression after 2 wks therapy
4. Rare peripheral neuropathy: with long term therapy
5. Optic neuropathy
6. Lactic acidosis
7. Black hairy tongue