Tetracyclines

Question 1

Generalizations of class

Answer 1

broad spectrum against gram-positive and negative bacteria
widespread resistance has developed
food can reduce absorption by 50%
monitor for PMC by Clostridium difficile

Question 2

therapeutic class

Answer 2

antibacterial

Question 3

pharmacologic class

Answer 3

protein synthesis inhibitor, tetracycline

Question 4

pregnancy category

Answer 4

D

Question 5

mechanism of action

Answer 5

inhibits protein synthesis by binding to 30s ribosomal subunit
interferes with attachment of tRNA to mRNA complex
terminates amino acid chain growth

Question 6

indications

Answer 6

gram-positive and negative bacteria

Question 7

contraindications

Answer 7

allergy to any drug in this class
pregnancy

Question 8

precautions

Answer 8

impaired hepatic or renal function

Question 9

drug interactions

Answer 9

calcium or iron supplements, laxatives wtih magnesium, and antacids reduce PO absorption and serum levels
decrease oral contraceptive effectiveness
dairy products affect absorption
increased anticoagulant efffect of warfarin

Question 10

adverse effects

Answer 10

DISCOLORATION of TEETH; superinfections, nausea, vomit, epigastric burning, diarrhea, photosensitivity, can worsen preexisting kidney impairment

Question 11

serious adverse effects

Answer 11

anaphylaxis, fatty degeneration of the liver; exfoliative dermatitis

Question 12

responsibilities

Answer 12

administer with full glass of water on empty stomach
do not give before sleep
report sudden onset of pain or dysphagia or diarrhea, monitor for superinfections; report headache or visual disturbance

Question 13

teaching

Answer 13

use good oral and skin care
protect eyes, nose and mouth from topicals
skin may look yellow to fluorescent green under UV/black lights
no antacids, calcium supplements, iron products and laxatives with magnesium
sunglasses, sunscreen when outside
no breast feeding and report pregnancy