Cephalosporins/Cefazolin

Question 1

Therapeutic Class

Answer 1

antibacterial

Question 2

Phamacologic class

Answer 2

cell wall inhibitor, first generation cephalosporin

Question 3

Pregnancy Category

Answer 3

B

Question 4

mechanism of action

Answer 4

inhibits bacterial wall synthesis by binding to specific PBPs; broad-spectrum bacteriocidal

Question 5

Indications

Answer 5

infections caused by gram positive and a few gram negative bacteria

Question 6

contraindications

Answer 6

allergy to any drug in this class

Question 7

precautions

Answer 7

hypersensitivity to penicillins

significant renal impairment since most is eliminated by kidneys

Question 8

drug interactions

Answer 8

increased risk of nephrotoxicity with nephrotoxic drugs
additive effect with other antibiotics
increases anticoagulant effect of warfarin

Question 9

adverse effects

Answer 9

rash, diarrhea, superinfections, pain and phlebitis at IM injection sites; allergic response

Question 10

serious adverse effects

Answer 10

hypersensitivity reactions; seizures

Question 11

nursing responsibilities

Answer 11

monitor first 30 minutes of IV therapy
monitor intake and output ratios
monitor for superinfections
report bleeding
assess IV sites during infusion
inject deep into muscle; rotate injection sites

Question 12

Teaching

Answer 12

consult before drinking alcohol; report signs of infection; report severe diarrhea; do not treat diarrhea with OTC; report bleeding or bruising; report allergic reactions