Fluconazole

Question 1

therapeutic class

Answer 1

antifungal

Question 2

pharmacologic class

Answer 2

inhibitor of fungal cell membrane synthesis, triazole (azole)

Question 3

pregnancy category

Answer 3

C

Question 4

mechanism of action

Answer 4

interferes with synthesis of ergosterol

Question 5

indications

Answer 5

infections by Candida albicans
cryptococcal meningitis
mycoses resistant to other antifungals

Question 6

contraindications

Answer 6

hypersensitivity to the drug or other azole

Question 7

precautions

Answer 7

hepatic impairment
hypokalemia
preexisting renal impairment

Question 8

drug interactions

Answer 8

may interact w/ drugs that induce or inhibit CYP2C9, 2C19, 3A4
PT time and risk for bleeding may increase w/ warfarin
certain oral glycemics may cause hypoglycemia
increased metabolism of fluconazole w/ rifampin

Question 9

adverse effects

Answer 9

nausea, vomiting, diarrha

Question 10

serious adverse effects

Answer 10

stevens-johnson syndrome in immunosuppressed patients

Question 11

responsibilities

Answer 11

monitor BUN, serum creatinine, and liver function lab tests
assess for allergic response
assess for hepatotoxicity

Question 12

teaching

Answer 12

report signs of liver toxicity
if diabetic, maintain blood sugar control
disclose all meds
report signs of drug allergy, known or suspected pregnancy