Test III Pt I Flashcards
Multifactorial polygenic disorders
Disorder that arises as a result of more than two relevant genes as well as environmental contributors
Schiz: diathesis stress theory
hizophrenia symptoms are triggered or worsened when environmental stressors (stress) act upon a biological vulnerability (diathesis) to the disease
Features of polygenic disorders
Gradations of severity
Not rare
Ill relatives appear in families of both parents
Predisposition to schiz
Polygenic disorder that causes predisposition
Schiz: assets and liabilities
Things that protect one from schiz
Lifetime risk for relatives of people with schiz
3% for second degree
10% for first degree
Morbid risk for children of schiz twins
Q
Concordance rate for MZ twins (schiz)
48%
Concordance rates for DZ twins (schiz)
17%
Concordance rate for identical twins reared apart (schiz)
64%
Most research for schiz supports which hypothesis?
Drift
4 Adoption research strategies (schiz)
- Examine grown up, adopted away offspring of parents w schiz
- Begin w grown up adoptees w schiz, and then evaluate psych status of bio and adoptive relatives
- Cross fostering
- Examine adopted away children of parents w schiz, and study their adoptive families longitudinally to contrast the families of those who develop schiz and those who don’t.
Hestons adoption study 1966
Morbid risk w schiz mom was 16% as compared to 0% in other adoptees
The Kety strategy
Begin with grown up adoptees w schiz, then evaluate psych status of bio and adoptive relatives. Kety found that schiz was far more prevalent in bio relatives.
Wender’s cross fostering research
4.8% of cross fostered group developed schiz
Why are psychosocial factors difficult to study? (4)
- Difficult to measure events occurring 10-20 years before onset of disorder
- Psychosocial processes are more subtle
- Events likely to act cumulatively
- Events interact with individual vulnerabilities
Schofield & Balian study of family risk factors
Examined what?
Findings?
Examined self reported early life histories of a group of people w schiz and a normal control group
Found normal controls and people w schiz did not differ in reports of early family problems
Schizophrenogenic mother
Schizo causing mother, who set it in motion by appearing to be self sacrificing but in reality are using the child as a means to meet their own needs
Vaughn and Leff’s study of relapse rates as a function of EE and medication
Suggests going home to family w high EE is a factor in relapse, especially when a lot of time is spent together.
Effectiveness of family intervention to prevent relapse
Studies suggest if you work w families on lowering EE it lowers the risk of relapse
Psychodynamic explanation (schiz)
Regression to pro ego stage
Efforts to reestablish ego control
Result of cold or unnurturing parents or trauma
Little research support
Behavioral view (schiz)
Operant conditioning reinforced for bizarre behaviors, but not reinforced for positive behaviors
Cognitive view (schiz)
Problems w attention, got confused and form unusual schemas. Delusions are their way of making sense of the schemas
Ethnic differences (schiz)
More blacks diagnosed with schiz and over represented in hospitals. More Mexicans than whites also
Course and outcome in developing countries (schiz)
Is better in less developed countries, probably due to family support
Social labeling (schiz)
Becomes self fulfilling prophecy that promotes its development
Double bind hypothesis (schiz)
Theory that some parents repeatedly communicate pairs of messages that are mutually contradictory, helping to produce schiz in their children
Expressed emotion (schiz)
General level of criticism, disapproval, and hostility expressed in a family