Test 3 ***

Question 1

Leukemia

Answer 1

A group of malignant disorders affecting the blood and blood forming tissues of bone marrow, lymph system, spleen

Question 2

Risks for leukemia

Answer 2

Abnormal chromosome
Exposure to ionizing radiation
Immune deficiencies
Down’s syndrome

Question 3

Acute myelogenous leukemia

Answer 3

25% of all leukemia
85% of acute leukemia in adults
Abrupt, dramatic onset
Serious infection or abnormal bleeding

Question 4

Acute myelogenous leukemia

Answer 4

Uncontrolled proliferation of myeloblasts

Hyperplasia of bone marrow and spleen

Question 5

Acute lymphocytic leukemia

ALL

Answer 5

Most common in children
10-15% of acute leukemia in adults
Immature lymphocytes proliferate in bone marrow
B-cell origin

Question 6

Sings and symptoms of ALL

Answer 6

Bruise, bleeding, fever, nosebleeds, weakness, pain, CNS manifestations HA

Question 7

Chronic myelogenous leukemia

Answer 7

Excessive mature neoplasticism granulocytes in bone marrow
Move to peripheral blood in massive numbers
Ultimately infiltrate liver and spleen

Question 8

Phases

Answer 8

Chronic (mild sysmptoms)
Accelerated (rapid/severe- doesn't respond to Tx) 
Blast phase( aggressive, METZ)

Question 9

Chronic lymphocytic leukemia

Answer 9

Production and accumulation of functionally inactive but long lived lymphocytes
Bcell involvement

Question 10

Complete goal

Answer 10

Physical exam, blood is normal

Question 11

Partial goal

Answer 11

Physical negative
Blood negative
Bone positive

Question 12

Molecular goal

Answer 12

All studies negative

Question 13

Stages of therapy

Induction

Answer 13

Achieve rapid, complete remission

Severe bone marrow suppression with neutropenia

Question 14

Consolidation

Answer 14

After remission is achieved
Intent is to cure
Single or repeated courses

Question 15

Maintenance

Answer 15

PO chemo for 2-5 years

Question 16

Drug

Answer 16

Gieevic
First line therapy for CML
+ philedephilia chromosome